PPRC1

Peroxisome proliferator-activated receptor gamma, coactivator-related 1
Identifiers
Symbols	PPRC1 ; KIAA0595; MGC74642; PRC; RP11-302K17.6
External IDs	Template:MGI HomoloGene: 9006
Gene ontology Molecular function Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PPRC1 203737 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Peroxisome proliferator-activated receptor gamma, coactivator-related 1, also known as PPRC1, is a human gene.

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.

Further reading

• Finck BN, Kelly DP (2006). "PGC-1 coactivators: inducible regulators of energy metabolism in health and disease". J. Clin. Invest. 116 (3): 615–22. doi:10.1172/JCI27794. PMID 16511594.
• Yamagata K, Yoshimochi K, Daitoku H; et al. (2007). "Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner". Int. J. Mol. Med. 19 (5): 751–6. PMID 17390079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srivastava S, Barrett JN, Moraes CT (2007). "PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations". Hum. Mol. Genet. 16 (8): 993–1005. doi:10.1093/hmg/ddm045. PMID 17341490.CS1 maint: Multiple names: authors list (link)
• Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMID 15684387.CS1 maint: Multiple names: authors list (link)
• Yamamoto T, Shimano H, Nakagawa Y; et al. (2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes". J. Biol. Chem. 279 (13): 12027–35. doi:10.1074/jbc.M310333200. PMID 14722127.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Savagner F, Mirebeau D, Jacques C; et al. (2003). "PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma". Biochem. Biophys. Res. Commun. 310 (3): 779–84. PMID 14550271.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scarpulla RC (2002). "Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells". Gene. 286 (1): 81–9. PMID 11943463.
• Andersson U, Scarpulla RC (2001). "Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells". Mol. Cell. Biol. 21 (11): 3738–49. doi:10.1128/MCB.21.11.3738-3749.2001. PMID 11340167.
• Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)