PRB4
| Proline-rich protein BstNI subfamily 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PRB4 ; Po | ||||||||||
| External IDs | Template:OMIM5 HomoloGene: 74447 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Proline-rich protein BstNI subfamily 4, also known as PRB4, is a human gene.[1]
The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.[1]
References
Further reading
- Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. PMID 3055850.
- Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. PMID 6810092.
- Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over". Genetics. 120 (1): 267–78. PMID 2851479.
- Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
- Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci". Genetics. 120 (1): 255–65. PMID 3220251.
- Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. PMID 6377992.
- Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. PMID 6841349.
- Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. PMID 8373986.
- Kim HS, Lyons KM, Saitoh E; et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. PMID 8422499.
- Azen EA, Amberger E, Fisher S; et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMID 8554050.
- Castle AM, Castle JD (1998). "Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein". Mol. Biol. Cell. 9 (3): 575–83. PMID 9487127.
- Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. PMID 11422372.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Vallat JM, Magy L, Lagrange E; et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201.
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