PRCP

Prolylcarboxypeptidase (angiotensinase C)
Identifiers
Symbols	PRCP ; PCP; HUMPCP; MGC2202
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55867
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PRCP 201494 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Prolylcarboxypeptidase (angiotensinase C), also known as PRCP, is a human gene.

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Further reading

• Odya CE, Marinkovic DV, Hammon KJ; et al. (1978). "Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney". J. Biol. Chem. 253 (17): 5927–31. PMID 28321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang HY, Erdös EG, Chiang TS (1968). "New enzymatic route for the inactivation of angiotensin". Nature. 218 (5148): 1224–6. PMID 4297812.CS1 maint: Multiple names: authors list (link)
• Jackman HL, Tan F, Schraufnagel D; et al. (1995). "Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages". Am. J. Respir. Cell Mol. Biol. 13 (2): 196–204. PMID 7626287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tan F, Morris PW, Skidgel RA, Erdös EG (1993). "Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families". J. Biol. Chem. 268 (22): 16631–8. PMID 8344943.CS1 maint: Multiple names: authors list (link)
• Watson B, Nowak NJ, Myracle AD; et al. (1997). "The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension". Genomics. 44 (3): 365–7. doi:10.1006/geno.1997.4883. PMID 9325062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shariat-Madar Z, Mahdi F, Schmaier AH (2002). "Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator". J. Biol. Chem. 277 (20): 17962–9. doi:10.1074/jbc.M106101200. PMID 11830581.CS1 maint: Multiple names: authors list (link)
• Moreira CR, Schmaier AH, Mahdi F; et al. (2002). "Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator". FEBS Lett. 523 (1–3): 167–70. PMID 12123826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shariat-Madar Z, Mahdi F, Schmaier AH (2004). "Recombinant prolylcarboxypeptidase activates plasma prekallikrein". Blood. 103 (12): 4554–61. doi:10.1182/blood-2003-07-2510. PMID 14996700.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Feng Y, Zhang Y; et al. (2006). "Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia". Am. J. Obstet. Gynecol. 195 (1): 162–71. doi:10.1016/j.ajog.2006.01.079. PMID 16681991.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)