PSMA7

Proteasome (prosome, macropain) subunit, alpha type, 7
File:PBB Protein PSMA7 image.jpg PDB rendering based on 1iru.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1iru​
Identifiers
Symbols	PSMA7 ; C6; HSPC; MGC3755; RC6-1; XAPC7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2086
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PSMA7 216088 s at tn.png
File:PBB GE PSMA7 201114 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Proteasome (prosome, macropain) subunit, alpha type, 7, also known as PSMA7, is a human gene.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.

Further reading

• Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.CS1 maint: Multiple names: authors list (link)
• Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1". Cell. 114 (3): 281–3. PMID 12914693.
• Kristensen P, Johnsen AH, Uerkvitz W; et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akioka H, Forsberg NE, Ishida N; et al. (1995). "Isolation and characterization of the HC8 subunit gene of the human proteasome". Biochem. Biophys. Res. Commun. 207 (1): 318–23. doi:10.1006/bbrc.1995.1190. PMID 7857283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang J, Kwong J, Sun EC, Liang TJ (1996). "Proteasome complex as a potential cellular target of hepatitis B virus X protein". J. Virol. 70 (8): 5582–91. PMID 8764072.CS1 maint: Multiple names: authors list (link)
• Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.CS1 maint: Multiple names: authors list (link)
• Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein". J. Virol. 72 (12): 10251–5. PMID 9811770.
• Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.CS1 maint: Multiple names: authors list (link)
• Elenich LA, Nandi D, Kent AE; et al. (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics. 49 (10): 835–42. PMID 10436176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Torii N, Furusaka A; et al. (2000). "Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex". J. Biol. Chem. 275 (20): 15157–65. doi:10.1074/jbc.M910378199. PMID 10748218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419.
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Y, Longo DL, Ferris DK (2001). "Polo-like kinase interacts with proteasomes and regulates their activity". Cell Growth Differ. 12 (1): 29–37. PMID 11205743.CS1 maint: Multiple names: authors list (link)
• Golubnitschaja-Labudova O, Liu R, Decker C; et al. (2001). "Altered gene expression in lymphocytes of patients with normal-tension glaucoma". Curr. Eye Res. 21 (5): 867–76. PMID 11262608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartmann-Petersen R, Tanaka K, Hendil KB (2001). "Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking". Arch. Biochem. Biophys. 386 (1): 89–94. doi:10.1006/abbi.2000.2178. PMID 11361004.CS1 maint: Multiple names: authors list (link)
• Cho S, Choi YJ, Kim JM; et al. (2001). "Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7". FEBS Lett. 498 (1): 62–6. PMID 11389899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krüger M, Beger C, Welch PJ; et al. (2001). "Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation". Mol. Cell. Biol. 21 (24): 8357–64. doi:10.1128/MCB.21.24.8357-8364.2001. PMID 11713272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein". Nature. 418 (6898): 646–50. doi:10.1038/nature00939. PMID 12167863.CS1 maint: Multiple names: authors list (link)