PTPRK

Protein tyrosine phosphatase, receptor type, K
File:PBB Protein PTPRK image.jpg PDB rendering based on 2c7s.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2c7s​
Identifiers
Symbols	PTPRK ; DKFZp686C2268; DKFZp779N1045; R-PTP-kappa
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55693
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTPRK 203038 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, K, also known as PTPRK, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.

Further reading

• Zondag GC, Koningstein GM, Jiang YP; et al. (1995). "Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain". J. Biol. Chem. 270 (24): 14247–50. PMID 7782276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sap J, Jiang YP, Friedlander D; et al. (1994). "Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding". Mol. Cell. Biol. 14 (1): 1–9. PMID 8264577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fuchs M, Müller T, Lerch MM, Ullrich A (1996). "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family". J. Biol. Chem. 271 (28): 16712–9. PMID 8663237.CS1 maint: Multiple names: authors list (link)
• Yang Y, Gil M, Byun SM; et al. (1997). "Transforming growth factor-beta1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression". Biochem. Biophys. Res. Commun. 228 (3): 807–12. doi:10.1006/bbrc.1996.1736. PMID 8941358.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Y, Gil MC, Choi EY; et al. (1997). "Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase". Gene. 186 (1): 77–82. PMID 9047348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Siebert R, Matthiesen P; et al. (1998). "Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3". Genomics. 51 (2): 309–11. doi:10.1006/geno.1998.5323. PMID 9722959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McArdle L, Rafferty M, Maelandsmo GM; et al. (2001). "Protein tyrosine phosphatase genes downregulated in melanoma". J. Invest. Dermatol. 117 (5): 1255–60. doi:10.1046/j.0022-202x.2001.01534.x. PMID 11710941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Novellino L, Renkvist N, Rini F; et al. (2003). "Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma antigen". J. Immunol. 170 (12): 6363–70. PMID 12794170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goehler H, Lalowski M, Stelzl U; et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu Y, Tan LJ, Grachtchouk V; et al. (2006). "Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function". J. Biol. Chem. 280 (52): 42694–700. doi:10.1074/jbc.M507722200. PMID 16263724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eswaran J, Debreczeni JE, Longman E; et al. (2006). "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500–5. doi:10.1110/ps.062128706. PMID 16672235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu Y, Shao Y, Voorhees JJ, Fisher GJ (2006). "Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes". J. Biol. Chem. 281 (37): 27389–97. doi:10.1074/jbc.M602355200. PMID 16849327.CS1 maint: Multiple names: authors list (link)