PTPRZ1

Protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Identifiers
Symbols	PTPRZ1 ; HPTPZ; HPTPzeta; PTP18; PTPRZ; PTPZ; RPTPB; RPTPbeta; phosphacan
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2136
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PTPRZ1 204469 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor-type, Z polypeptide 1, also known as PTPRZ1, is a human gene.

This gene is a member of the receptor type protein tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type-III domain. Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Further reading

• Krueger NX, Saito H (1992). "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7417–21. PMID 1323835.
• Kaplan R, Morse B, Huebner K; et al. (1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7000–4. PMID 2169617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". EMBO J. 9 (10): 3241–52. PMID 2170109.CS1 maint: Multiple names: authors list (link)
• Ariyama T, Hasegawa K, Inazawa J; et al. (1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet. Cell Genet. 70 (1–2): 52–4. PMID 7736789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levy JB, Canoll PD, Silvennoinen O; et al. (1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J. Biol. Chem. 268 (14): 10573–81. PMID 8387522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morton SM, Veile RA, Helms C; et al. (1998). "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics. 46 (3): 491–4. doi:10.1006/geno.1997.5051. PMID 9441757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Onyango P, Lubyova B, Gardellin P; et al. (1998). "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics. 50 (2): 187–98. doi:10.1006/geno.1997.5186. PMID 9653645.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Maeda N, Ichihara-Tanaka K, Kimura T; et al. (1999). "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta". J. Biol. Chem. 274 (18): 12474–9. PMID 10212223.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawachi H, Tamura H, Watakabe I; et al. (1999). "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family". Brain Res. Mol. Brain Res. 72 (1): 47–54. PMID 10521598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meng K, Rodriguez-Peña A, Dimitrov T; et al. (2000). "Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2603–8. doi:10.1073/pnas.020487997. PMID 10706604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawachi H, Fujikawa A, Maeda N, Noda M (2001). "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6593–8. doi:10.1073/pnas.041608698. PMID 11381105.CS1 maint: Multiple names: authors list (link)
• Thomaidou D, Coquillat D, Meintanis S; et al. (2001). "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". J. Neurochem. 78 (4): 767–78. PMID 11520897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harroch S, Furtado GC, Brueck W; et al. (2002). "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nat. Genet. 32 (3): 411–4. doi:10.1038/ng1004. PMID 12355066.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Müller S, Kunkel P, Lamszus K; et al. (2003). "A role for receptor tyrosine phosphatase zeta in glioma cell migration". Oncogene. 22 (43): 6661–8. doi:10.1038/sj.onc.1206763. PMID 14555979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonora E, Lamb JA, Barnby G; et al. (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi:10.1038/sj.ejhg.5201315. PMID 15523497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Polykratis A, Katsoris P, Courty J, Papadimitriou E (2005). "Characterization of heparin affin regulatory peptide signaling in human endothelial cells". J. Biol. Chem. 280 (23): 22454–61. doi:10.1074/jbc.M414407200. PMID 15797857.CS1 maint: Multiple names: authors list (link)
• Wang V, Davis DA, Haque M; et al. (2005). "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Res. 65 (8): 3299–306. doi:10.1158/0008-5472.CAN-04-4130. PMID 15833863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu KV, Jong KA, Kim GY; et al. (2005). "Differential induction of glioblastoma migration and growth by two forms of pleiotrophin". J. Biol. Chem. 280 (29): 26953–64. doi:10.1074/jbc.M502614200. PMID 15908427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)