Peptidyl-glutamyl peptide-hydrolyzing activity

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Peptidyl-glutamyl peptide-hydrolyzing (PGPH) enzyme activity is a means of proteolysis that cleaves peptide bonds in proteins immediately after acidic or branched-chain amino acids. One of the three catalytic β subunits of the proteasome has PGPH activity and is strongly inhibited by the proteasome inhibitor epoxomicin.[1]

References

  1. ↑ Meng L, Mohan R, Kwok BHB, Elofsson M, Sin N, Crews CM. (1999). Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci USA 96(18): 10403-10408.

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