Prohibitin

Prohibitin
Identifiers
Symbols	PHB ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1980
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PHB 200658 s at tn.png
File:PBB GE PHB 200659 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Prohibitin, also known as PHB, is a human gene.

Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

Further reading

• McClung JK, Jupe ER, Liu XT, Dell'Orco RT (1996). "Prohibitin: potential role in senescence, development, and tumor suppression". Exp. Gerontol. 30 (2): 99–124. PMID 8591812.CS1 maint: Multiple names: authors list (link)
• Dell'Orco RT, McClung JK, Jupe ER, Liu XT (1996). "Prohibitin and the senescent phenotype". Exp. Gerontol. 31 (1–2): 245–52. PMID 8706794.CS1 maint: Multiple names: authors list (link)
• Mishra S, Murphy LC, Nyomba BL, Murphy LJ (2005). "Prohibitin: a potential target for new therapeutics". Trends in molecular medicine. 11 (4): 192–7. doi:10.1016/j.molmed.2005.02.004. PMID 15823758.CS1 maint: Multiple names: authors list (link)
• Rajalingam K, Rudel T (2007). "Ras-Raf signaling needs prohibitin". Cell Cycle. 4 (11): 1503–5. PMID 16294014.
• Sato T, Saito H, Swensen J; et al. (1992). "The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer". Cancer Res. 52 (6): 1643–6. PMID 1540973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• White JJ, Ledbetter DH, Eddy RL; et al. (1992). "Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism". Genomics. 11 (1): 228–30. PMID 1684951.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Altus MS, Wood CM, Stewart DA; et al. (1995). "Regions of evolutionary conservation between the rat and human prohibitin-encoding genes". Gene. 158 (2): 291–4. PMID 7607556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikonen E, Fiedler K, Parton RG, Simons K (1995). "Prohibitin, an antiproliferative protein, is localized to mitochondria". FEBS Lett. 358 (3): 273–7. PMID 7843414.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Sato T, Sakamoto T, Takita K; et al. (1993). "The human prohibitin (PHB) gene family and its somatic mutations in human tumors". Genomics. 17 (3): 762–4. PMID 8244394.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jupe ER, Liu XT, Kiehlbauch JL; et al. (1996). "The 3' untranslated region of prohibitin and cellular immortalization". Exp. Cell Res. 224 (1): 128–35. doi:10.1006/excr.1996.0120. PMID 8612677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rasmussen RK, Ji H, Eddes JS; et al. (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis. 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang S, Nath N, Adlam M, Chellappan S (1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene. 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. PMID 10376528.CS1 maint: Multiple names: authors list (link)
• Wang S, Nath N, Fusaro G, Chellappan S (1999). "Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals". Mol. Cell. Biol. 19 (11): 7447–60. PMID 10523633.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Coates PJ, Nenutil R, McGregor A; et al. (2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Exp. Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID 11302691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)