QSOX1

Quiescin Q6
Identifiers
Symbols	QSCN6 ; Q6; QSOX1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37690
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE QSCN6 201482 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Quiescin Q6, also known as QSCN6, is a human gene.

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.

Further reading

• Thorpe C, Hoober KL, Raje S; et al. (2002). "Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes". Arch. Biochem. Biophys. 405 (1): 1–12. PMID 12176051.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coppock DL, Kopman C, Scandalis S, Gilleran S (1993). "Preferential gene expression in quiescent human lung fibroblasts". Cell Growth Differ. 4 (6): 483–93. PMID 8396966.CS1 maint: Multiple names: authors list (link)
• Coppock DL, Cina-Poppe D, Gilleran S (1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1". Genomics. 54 (3): 460–8. doi:10.1006/geno.1998.5605. PMID 9878249.CS1 maint: Multiple names: authors list (link)
• Hoober KL, Glynn NM, Burnside J; et al. (1999). "Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases". J. Biol. Chem. 274 (45): 31759–62. PMID 10542195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coppock D, Kopman C, Gudas J, Cina-Poppe DA (2000). "Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29". Biochem. Biophys. Res. Commun. 269 (2): 604–10. doi:10.1006/bbrc.2000.2324. PMID 10708601.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radom J, Colin D, Thiebault F; et al. (2006). "Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain". Biochim. Biophys. Acta. 1759 (5): 225–33. doi:10.1016/j.bbaexp.2006.04.008. PMID 16806532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chakravarthi S, Jessop CE, Willer M; et al. (2007). "Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1". Biochem. J. 404 (3): 403–11. doi:10.1042/BJ20061510. PMID 17331072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaje J, Wolcott HN, Fadugba O; et al. "A flavin-dependent sulfhydryl oxidase in bovine milk". Biochemistry. 46 (45): 13031–40. doi:10.1021/bi7016975. PMID 17944490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)