RALA

V-ral simian leukemia viral oncogene homolog A (ras related)
File:PBB Protein RALA image.jpg PDB rendering based on 1u8y.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1u8y​, 1u8z​, 1u90​, 1uad​, 1zc3​, 1zc4​, 2a78​, 2a9k​, 2bov​
Identifiers
Symbols	RALA ; MGC48949; RAL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3942
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RALA 214435 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

V-ral simian leukemia viral oncogene homolog A (ras related), also known as RALA, is a human gene.

The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.

Further reading

• Kinsella BT, Erdman RA, Maltese WA (1991). "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA". J. Biol. Chem. 266 (15): 9786–94. PMID 1903399.CS1 maint: Multiple names: authors list (link)
• Polakis PG, Weber RF, Nevins B; et al. (1989). "Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets". J. Biol. Chem. 264 (28): 16383–9. PMID 2550440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chardin P, Tavitian A (1989). "Coding sequences of human ralA and ralB cDNAs". Nucleic Acids Res. 17 (11): 4380. PMID 2662142.
• Rousseau-Merck MF, Bernheim A, Chardin P; et al. (1988). "The ras-related ral gene maps to chromosome 7p15-22". Hum. Genet. 79 (2): 132–6. PMID 3292391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cantor SB, Urano T, Feig LA (1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Mol. Cell. Biol. 15 (8): 4578–84. PMID 7623849.CS1 maint: Multiple names: authors list (link)
• Jullien-Flores V, Dorseuil O, Romero F; et al. (1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. 270 (38): 22473–7. PMID 7673236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang KL, Khan MT, Roufogalis BD (1997). "Identification and characterization of a calmodulin-binding domain in Ral-A, a Ras-related GTP-binding protein purified from human erythrocyte membrane". J. Biol. Chem. 272 (25): 16002–9. PMID 9188503.CS1 maint: Multiple names: authors list (link)
• Luo JQ, Liu X, Hammond SM; et al. (1997). "RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1". Biochem. Biophys. Res. Commun. 235 (3): 854–9. doi:10.1006/bbrc.1997.6793. PMID 9207251.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda M, Ishida O, Hinoi T; et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. PMID 9422736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vavvas D, Li X, Avruch J, Zhang XF (1998). "Identification of Nore1 as a potential Ras effector". J. Biol. Chem. 273 (10): 5439–42. PMID 9488663.CS1 maint: Multiple names: authors list (link)
• Kim JH, Lee SD, Han JM; et al. (1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Lett. 430 (3): 231–5. PMID 9688545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohta Y, Suzuki N, Nakamura S; et al. (1999). "The small GTPase RalA targets filamin to induce filopodia". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2122–8. PMID 10051605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang KL, Roufogalis BD (1999). "Ca2+/calmodulin stimulates GTP binding to the ras-related protein ral-A". J. Biol. Chem. 274 (21): 14525–8. PMID 10329639.
• Suzuki J, Yamazaki Y, Li G; et al. (2000). "Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts". Mol. Cell. Biol. 20 (13): 4658–65. PMID 10848592.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Bruyn KM, de Rooij J, Wolthuis RM; et al. (2000). "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral". J. Biol. Chem. 275 (38): 29761–6. doi:10.1074/jbc.M001160200. PMID 10889189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brymora A, Valova VA, Larsen MR; et al. (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugihara K, Asano S, Tanaka K; et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID 11744922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clough RR, Sidhu RS, Bhullar RP (2002). "Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets". J. Biol. Chem. 277 (32): 28972–80. doi:10.1074/jbc.M201504200. PMID 12034722.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu L, Frankel P, Jackson D; et al. (2003). "Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6". Mol. Cell. Biol. 23 (2): 645–54. PMID 12509462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)