RALB

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
Identifiers
Symbols	RALB ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20632
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RALB 202100 at tn.png
File:PBB GE RALB 202101 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein), also known as RALB, is a human gene.

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.

Further reading

• Hsieh CL, Swaroop A, Francke U (1990). "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein". Somat. Cell Mol. Genet. 16 (4): 407–10. PMID 2120779.CS1 maint: Multiple names: authors list (link)
• Chardin P, Tavitian A (1989). "Coding sequences of human ralA and ralB cDNAs". Nucleic Acids Res. 17 (11): 4380. PMID 2662142.
• Jullien-Flores V, Dorseuil O, Romero F; et al. (1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. 270 (38): 22473–7. PMID 7673236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jilkina O, Bhullar RP (1997). "Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets". Biochim. Biophys. Acta. 1314 (1–2): 157–66. PMID 8972729.
• Ikeda M, Ishida O, Hinoi T; et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. PMID 9422736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugihara K, Asano S, Tanaka K; et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID 11744922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clough RR, Sidhu RS, Bhullar RP (2002). "Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets". J. Biol. Chem. 277 (32): 28972–80. doi:10.1074/jbc.M201504200. PMID 12034722.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chien Y, White MA (2004). "RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival". EMBO Rep. 4 (8): 800–6. doi:10.1038/sj.embor.embor899. PMID 12856001.
• Hernández-Muñoz I, Benet M, Calero M; et al. (2003). "rgr oncogene: activation by elimination of translational controls and mislocalization". Cancer Res. 63 (14): 4188–95. PMID 12874025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moskalenko S, Tong C, Rosse C; et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sidhu RS, Clough RR, Bhullar RP (2005). "Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin". J. Biol. Chem. 280 (23): 21933–41. doi:10.1074/jbc.M412966200. PMID 15817490.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chien Y, Kim S, Bumeister R; et al. (2006). "RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival". Cell. 127 (1): 157–70. doi:10.1016/j.cell.2006.08.034. PMID 17018283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim KH, O'Hayer K, Adam SJ; et al. (2007). "Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells". Curr. Biol. 16 (24): 2385–94. doi:10.1016/j.cub.2006.10.023. PMID 17174914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith SC, Oxford G, Baras AS; et al. (2007). "Expression of ral GTPases, their effectors, and activators in human bladder cancer". Clin. Cancer Res. 13 (13): 3803–13. doi:10.1158/1078-0432.CCR-06-2419. PMID 17606711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yin J, Pollock C, Tracy K; et al. (2007). "Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone". Mol. Cell. Biol. 27 (21): 7538–50. doi:10.1128/MCB.00955-07. PMID 17709381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)