RASSF2

Ras association (RalGDS/AF-6) domain family 2
Identifiers
Symbols	RASSF2 ; DKFZp781O1747; KIAA0168
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22840
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RASSF2 203185 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ras association (RalGDS/AF-6) domain family 2, also known as RASSF2, is a human gene.

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Nagase T, Seki N, Ishikawa K; et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. PMID 8724849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Comincini S, Castiglioni BM, Foti GM; et al. (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene". Mamm. Genome. 12 (2): 150–6. PMID 11210185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vos MD, Ellis CA, Elam C; et al. (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. PMID 12732644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita H, Fukuhara S, Sakurai A; et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hesson LB, Wilson R, Morton D; et al. (2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akino K, Toyota M, Suzuki H; et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. 129 (1): 156–69. PMID 16012945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endoh M, Tamura G, Honda T; et al. (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer". Br. J. Cancer. 93 (12): 1395–9. doi:10.1038/sj.bjc.6602854. PMID 16265349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Sun D, Van do N; et al. (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma". Int. J. Cancer. 120 (1): 32–8. doi:10.1002/ijc.22185. PMID 17013896.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park HW, Kang HC, Kim IJ; et al. (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers". Int. J. Cancer. 120 (1): 7–12. doi:10.1002/ijc.22276. PMID 17013898.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumari G, Singhal PK, Rao MR, Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals". J. Mol. Biol. 367 (5): 1294–311. doi:10.1016/j.jmb.2007.01.026. PMID 17320110.CS1 maint: Multiple names: authors list (link)
• Kaira K, Sunaga N, Tomizawa Y; et al. (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers". Int. J. Oncol. 31 (1): 169–73. PMID 17549418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)