RFC1

Replication factor C (activator 1) 1, 145kDa
Identifiers
Symbols	RFC1 ; A1; MGC51786; MHCBFB; PO-GA; RECC1; RFC; RFC140
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2187
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RFC1 208021 s at tn.png
File:PBB GE RFC1 209085 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Replication factor C (activator 1) 1, 145kDa, also known as RFC1, is a human gene.

The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.

Further reading

• Lu Y, Riegel AT (1994). "The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA". Gene. 145 (2): 261–5. PMID 7914507.
• Luckow B, Bunz F, Stillman B; et al. (1994). "Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans". Mol. Cell. Biol. 14 (3): 1626–34. PMID 8114700.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bunz F, Kobayashi R, Stillman B (1994). "cDNAs encoding the large subunit of human replication factor C.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11014–8. PMID 8248204.CS1 maint: Multiple names: authors list (link)
• Lu Y, Zeft AS, Riegel AT (1993). "Cloning and expression of a novel human DNA binding protein, PO-GA". Biochem. Biophys. Res. Commun. 193 (2): 779–86. doi:10.1006/bbrc.1993.1693. PMID 8512577.CS1 maint: Multiple names: authors list (link)
• Uhlmann F, Cai J, Flores-Rozas H; et al. (1996). "In vitro reconstitution of human replication factor C from its five subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. PMID 8692848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fotedar R, Mossi R, Fitzgerald P; et al. (1996). "A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells". EMBO J. 15 (16): 4423–33. PMID 8861969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uchiumi F, Ohta T, Tanuma S (1997). "Replication factor C recognizes 5'-phosphate ends of telomeres". Biochem. Biophys. Res. Commun. 229 (1): 310–5. PMID 8954124.CS1 maint: Multiple names: authors list (link)
• Mossi R, Jónsson ZO, Allen BL; et al. (1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen". J. Biol. Chem. 272 (3): 1769–76. PMID 8999859.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cujec TP, Cho H, Maldonado E; et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ubeda M, Habener JF (1997). "The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis". J. Biol. Chem. 272 (31): 19562–8. PMID 9235961.
• Rhéaume E, Cohen LY, Uhlmann F; et al. (1998). "The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis". EMBO J. 16 (21): 6346–54. doi:10.1093/emboj/16.21.6346. PMID 9351817.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ellison V, Stillman B (1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. 273 (10): 5979–87. PMID 9488738.
• Coll JM, Hickey RJ, Cronkey EA; et al. (1998). "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome". Oncol. Res. 9 (11–12): 629–39. PMID 9563011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allen BL, Uhlmann F, Gaur LK; et al. (1998). "DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C.". Nucleic Acids Res. 26 (17): 3877–82. PMID 9705493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Kuip H, Carius B, Haque SJ; et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. PMID 10353443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Cortez D, Yazdi P; et al. (2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes Dev. 14 (8): 927–39. PMID 10783165.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yazdi PT, Wang Y, Zhao S; et al. (2002). "SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint". Genes Dev. 16 (5): 571–82. doi:10.1101/gad.970702. PMID 11877377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson LA, Perkins ND (2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1". J. Biol. Chem. 277 (33): 29550–4. doi:10.1074/jbc.M200513200. PMID 12045192.
• Ohta S, Shiomi Y, Sugimoto K; et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama T, Farina A, Dey A; et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)