RFC2

Replication factor C (activator 1) 2, 40kDa
Identifiers
Symbols	RFC2 ; A1; MGC3665; RFC40
External IDs	Template:OMIM5 Template:MGI HomoloGene: 6885
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE RFC2 1053 at tn.png
File:PBB GE RFC2 203696 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Replication factor C (activator 1) 2, 40kDa, also known as RFC2, is a human gene.

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Chen M, Pan ZQ, Hurwitz J (1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2516–20. PMID 1313560.CS1 maint: Multiple names: authors list (link)
• Okumura K, Nogami M, Taguchi H; et al. (1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. PMID 7774928.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pan ZQ, Chen M, Hurwitz J (1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 6–10. PMID 8093561.CS1 maint: Multiple names: authors list (link)
• Peoples R, Perez-Jurado L, Wang YK; et al. (1996). "The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion". Am. J. Hum. Genet. 58 (6): 1370–3. PMID 8651315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uhlmann F, Cai J, Flores-Rozas H; et al. (1996). "In vitro reconstitution of human replication factor C from its five subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. PMID 8692848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Osborne LR, Martindale D, Scherer SW; et al. (1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cujec TP, Cho H, Maldonado E; et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cai J, Gibbs E, Uhlmann F; et al. (1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". J. Biol. Chem. 272 (30): 18974–81. PMID 9228079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ellison V, Stillman B (1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. 273 (10): 5979–87. PMID 9488738.
• Zhang G, Gibbs E, Kelman Z; et al. (1999). "Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. PMID 10051561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Cortez D, Yazdi P; et al. (2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes Dev. 14 (8): 927–39. PMID 10783165.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martindale DW, Wilson MD, Wang D; et al. (2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mamm. Genome. 11 (10): 890–8. PMID 11003705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Griffith JD, Lindsey-Boltz LA, Sancar A (2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". J. Biol. Chem. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025.CS1 maint: Multiple names: authors list (link)
• Nieborowska-Skorska M, Hoser G, Kossev P; et al. (2002). "Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis". Blood. 99 (12): 4531–9. PMID 12036885.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohta S, Shiomi Y, Sugimoto K; et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama T, Farina A, Dey A; et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J. Biol. Chem. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bermudez VP, Maniwa Y, Tappin I; et al. (2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMID 12930902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)