RGN (gene)

Regucalcin (senescence marker protein-30)
Identifiers
Symbols	RGN ; RC; SMP30
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3437
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RGN 210751 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Regucalcin (senescence marker protein-30), also known as RGN, is a human gene.

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.

Further reading

• Fujita T, Shirasawa T, Maruyama N (1999). "Expression and structure of senescence marker protein-30 (SMP30) and its biological significance". Mech. Ageing Dev. 107 (3): 271–80. PMID 10360682.CS1 maint: Multiple names: authors list (link)
• Fujita T, Mandel JL, Shirasawa T; et al. (1995). "Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome". Biochim. Biophys. Acta. 1263 (3): 249–52. PMID 7548213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Misawa H, Yamaguchi M (2000). "Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin". Int. J. Mol. Med. 5 (3): 283–7. PMID 10677570.
• Thiselton DL, McDowall J, Brandau O; et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishigami A, Handa S, Maruyama N, Supakar PC (2003). "Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase". Biosci. Biotechnol. Biochem. 67 (1): 158–60. PMID 12619687.CS1 maint: Multiple names: authors list (link)
• Matsuyama S, Kitamura T, Enomoto N; et al. (2004). "Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells". Biochem. Biophys. Res. Commun. 321 (2): 386–90. doi:10.1016/j.bbrc.2004.06.161. PMID 15358188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warizaya M, Kinoshita T, Yamaoka M; et al. (2005). "Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 11): 2019–21. doi:10.1107/S0907444904020608. PMID 15502314.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishigami A, Fujita T, Inoue H; et al. (2005). "Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells". Cell Tissue Res. 320 (2): 243–9. doi:10.1007/s00441-004-1073-5. PMID 15714273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaguchi M, Daimon Y (2005). "Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes". J. Cell. Biochem. 95 (6): 1169–77. doi:10.1002/jcb.20490. PMID 15962315.