RGS3
| Regulator of G-protein signalling 3 | |||||||||||||
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File:PBB Protein RGS3 image.jpg PDB rendering based on 2f5y. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RGS3 ; C2PA; FLJ20370; FLJ31516; FLJ90496; PDZ-RGS3; RGP3 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 32440 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE RGS3 203823 at tn.png | |||||||||||||
| File:PBB GE RGS3 220300 at tn.png | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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Regulator of G-protein signalling 3, also known as RGS3, is a human gene.[1]
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
- Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). "Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene". Genomics. 45 (2): 429–33. doi:10.1006/geno.1997.4929. PMID 9344672.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Dulin NO, Sorokin A, Reed E; et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11". Mol. Cell. Biol. 19 (1): 714–23. PMID 9858594.
- Dulin NO, Pratt P, Tiruppathi C; et al. (2000). "Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis". J. Biol. Chem. 275 (28): 21317–23. doi:10.1074/jbc.M910079199. PMID 10749886.
- Linares JL, Wendling C, Tomasetto C, Rio MC (2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett. 480 (2–3): 249–54. PMID 11034339.
- Shi CS, Lee SB, Sinnarajah S; et al. (2001). "Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation". J. Biol. Chem. 276 (26): 24293–300. doi:10.1074/jbc.M100089200. PMID 11294858.
- Lu Q, Sun EE, Klein RS, Flanagan JG (2001). "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction". Cell. 105 (1): 69–79. PMID 11301003.
- Mittmann C, Schüler C, Chung CH; et al. (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart". Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456–63. PMID 11330340.
- Niu J, Scheschonka A, Druey KM; et al. (2002). "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain". Biochem. J. 365 (Pt 3): 677–84. doi:10.1042/BJ20020390. PMID 11985497.
- Kehrl JH, Srikumar D, Harrison K; et al. (2002). "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3". Genomics. 79 (6): 860–8. doi:10.1006/geno.2002.6773. PMID 12036301.
- Ikeda M, Okai M, Miyoshi T; et al. (2003). "Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha". Horm. Metab. Res. 34 (8): 425–30. doi:10.1055/s-2002-33599. PMID 12198596.
- Hirabayashi S, Ohno H, Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
- Tovey SC, Willars GB (2005). "Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor". Mol. Pharmacol. 66 (6): 1453–64. doi:10.1124/mol.104.005827. PMID 15383626.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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