RIPK2

Receptor-interacting serine-threonine kinase 2
Identifiers
Symbols	RIPK2 ; CCK; CARD3; CARDIAK; GIG30; RICK; RIP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37856
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RIPK2 209544 at tn.png
File:PBB GE RIPK2 209545 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Receptor-interacting serine-threonine kinase 2, also known as RIPK2, is a human gene.

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.

Further reading

• Medzhitov R, Janeway C (2000). "Innate immune recognition: mechanisms and pathways". Immunol. Rev. 173: 89–97. PMID 10719670.
• Dufner A, Mak TW (2006). "CARD tricks: controlling the interactions of CARD6 with RICK and microtubules". Cell Cycle. 5 (8): 797–800. PMID 16582588.
• Inohara N, del Peso L, Koseki T; et al. (1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J. Biol. Chem. 273 (20): 12296–300. PMID 9575181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. 273 (27): 16968–75. PMID 9642260.CS1 maint: Multiple names: authors list (link)
• Thome M, Hofmann K, Burns K; et al. (1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr. Biol. 8 (15): 885–8. PMID 9705938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertin J, Nir WJ, Fischer CM; et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". J. Biol. Chem. 274 (19): 12955–8. PMID 10224040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inohara N, Koseki T, del Peso L; et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". J. Biol. Chem. 274 (21): 14560–7. PMID 10329646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Navas TA, Baldwin DT, Stewart TA (1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase". J. Biol. Chem. 274 (47): 33684–90. PMID 10559258.CS1 maint: Multiple names: authors list (link)
• Inohara N, Koseki T, Lin J; et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". J. Biol. Chem. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogura Y, Inohara N, Benito A; et al. (2001). "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB". J. Biol. Chem. 276 (7): 4812–8. doi:10.1074/jbc.M008072200. PMID 11087742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing". J. Biol. Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.CS1 maint: Multiple names: authors list (link)
• Khursigara G, Bertin J, Yano H; et al. (2001). "A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2". J. Neurosci. 21 (16): 5854–63. PMID 11487608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Druilhe A, Srinivasula SM, Razmara M; et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj/cdd/4400881. PMID 11536016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chin AI, Dempsey PW, Bruhn K; et al. (2002). "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses". Nature. 416 (6877): 190–4. doi:10.1038/416190a. PMID 11894097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi K, Inohara N, Hernandez LD; et al. (2002). "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems". Nature. 416 (6877): 194–9. doi:10.1038/416194a. PMID 11894098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Munz B, Hildt E, Springer ML, Blau HM (2002). "RIP2, a checkpoint in myogenic differentiation". Mol. Cell. Biol. 22 (16): 5879–86. PMID 12138198.CS1 maint: Multiple names: authors list (link)
• Yoo NJ, Park WS, Kim SY; et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochem. Biophys. Res. Commun. 299 (4): 652–8. PMID 12459189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen YR, Clark AC (2003). "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK". Biochemistry. 42 (20): 6310–20. doi:10.1021/bi0340752. PMID 12755636.