RIPK3

Receptor-interacting serine-threonine kinase 3
Identifiers
Symbols	RIPK3 ; RIP3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31410
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Receptor-interacting serine-threonine kinase 3, also known as RIPK3, is a human gene.

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Further reading

• Yu PW, Huang BC, Shen M; et al. (1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr. Biol. 9 (10): 539–42. PMID 10339433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun X, Lee J, Navas T; et al. (1999). "RIP3, a novel apoptosis-inducing kinase". J. Biol. Chem. 274 (24): 16871–5. PMID 10358032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kasof GM, Prosser JC, Liu D; et al. (2000). "The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria". FEBS Lett. 473 (3): 285–91. PMID 10818227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun X, Yin J, Starovasnik MA; et al. (2002). "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3". J. Biol. Chem. 277 (11): 9505–11. doi:10.1074/jbc.M109488200. PMID 11734559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meylan E, Burns K, Hofmann K; et al. (2004). "RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation". Nat. Immunol. 5 (5): 503–7. doi:10.1038/ni1061. PMID 15064760.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Y, Ma J, Chen Y, Wu M (2004). "Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3". J. Biol. Chem. 279 (37): 38820–9. doi:10.1074/jbc.M401663200. PMID 15208320.CS1 maint: Multiple names: authors list (link)
• Yang Y, Hu W, Feng S; et al. (2005). "RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis". Biochem. Biophys. Res. Commun. 332 (1): 181–7. doi:10.1016/j.bbrc.2005.04.114. PMID 15896315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao L, Wang G, Lu D; et al. (2006). "Homocysteine, hRIP3 and congenital cardiovascular malformations". Anat. Embryol. 211 (3): 203–12. doi:10.1007/s00429-005-0074-9. PMID 16429275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng S, Ma L, Yang Y, Wu M (2006). "Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703". Biochem. Biophys. Res. Commun. 347 (3): 558–65. doi:10.1016/j.bbrc.2006.06.118. PMID 16844082.CS1 maint: Multiple names: authors list (link)
• Ahn KS, Sethi G, Krishnan K, Aggarwal BB (2007). "Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis". J. Biol. Chem. 282 (1): 809–20. doi:10.1074/jbc.M610028200. PMID 17114179.CS1 maint: Multiple names: authors list (link)