RNF14

Ring finger protein 14
Identifiers
Symbols	RNF14 ; ARA54; FLJ26004; HFB30; HRIHFB2038
External IDs	Template:OMIM5 Template:MGI HomoloGene: 6573
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RNF14 201823 s at tn.png
File:PBB GE RNF14 201824 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ring finger protein 14, also known as RNF14, is a human gene.

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.

See also

• RING finger domain

Further reading

• Ueki N, Oda T, Kondo M; et al. (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J. Biol. Chem. 274 (13): 8570–6. PMID 10085091.CS1 maint: Multiple names: authors list (link)
• Ueki N, Seki N, Yano K; et al. (1999). "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif". Biochim. Biophys. Acta. 1445 (2): 232–6. PMID 10320776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito K, Adachi S, Iwakami R; et al. (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. PMID 11322894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyamoto H, Rahman M, Takatera H; et al. (2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. doi:10.1074/jbc.M108312200. PMID 11673464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. doi:10.1074/jbc.M203313200. PMID 12163482.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He B, Wilson EM (2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. PMID 12612084.
• Mestayer C, Blanchère M, Jaubert F; et al. (2003). "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines". Prostate. 56 (3): 192–200. doi:10.1002/pros.10229. PMID 12772188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Hsu CL, Ni J; et al. (2004). "Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells". Mol. Cell. Biol. 24 (5): 2202–13. PMID 14966297.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin DY, Fang HI, Ma AH; et al. (2004). "Negative modulation of androgen receptor transcriptional activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Chang YJ, Miyamoto H; et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Chang YJ, Miyamoto H; et al. (2007). "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54". Endocrinology. 148 (3): 1340–9. doi:10.1210/en.2006-0716. PMID 17110431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kikuchi H, Uchida C, Hattori T; et al. (2007). "ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells". Carcinogenesis. 28 (8): 1752–8. doi:10.1093/carcin/bgm120. PMID 17510080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• RNF14+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)