ROS1 (gene)

V-ros UR2 sarcoma virus oncogene homolog 1 (avian)
Identifiers
Symbols	ROS1 ; MCF3; ROS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2207
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ROS1 207569 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

V-ros UR2 sarcoma virus oncogene homolog 1 (avian), also known as ROS1, is a human gene.

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.

Further reading

• Galland F, Stefanova M, Lafage M, Birnbaum D (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet. Cell Genet. 60 (2): 114–6. PMID 1611909.CS1 maint: Multiple names: authors list (link)
• Birchmeier C, O'Neill K, Riggs M, Wigler M (1990). "Characterization of ROS1 cDNA from a human glioblastoma cell line". Proc. Natl. Acad. Sci. U.S.A. 87 (12): 4799–803. PMID 2352949.CS1 maint: Multiple names: authors list (link)
• Sharma S, Birchmeier C, Nikawa J; et al. (1990). "Characterization of the ros1-gene products expressed in human glioblastoma cell lines". Oncogene Res. 5 (2): 91–100. PMID 2691958.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birchmeier C, Sharma S, Wigler M (1988). "Expression and rearrangement of the ROS1 gene in human glioblastoma cells". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9270–4. PMID 2827175.CS1 maint: Multiple names: authors list (link)
• Matsushime H, Wang LH, Shibuya M (1987). "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule". Mol. Cell. Biol. 6 (8): 3000–4. PMID 3023956.CS1 maint: Multiple names: authors list (link)
• Satoh H, Yoshida MC, Matsushime H; et al. (1987). "Regional localization of the human c-ros-1 on 6q22 and flt on 13q12". Jpn. J. Cancer Res. 78 (8): 772–5. PMID 3115921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birchmeier C, Birnbaum D, Waitches G; et al. (1986). "Characterization of an activated human ros gene". Mol. Cell. Biol. 6 (9): 3109–16. PMID 3785223.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sonnenberg-Riethmacher E, Walter B, Riethmacher D; et al. (1996). "The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis". Genes Dev. 10 (10): 1184–93. PMID 8675006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zeng L, Sachdev P, Yan L; et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–24. PMID 11094073.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Keilhack H, Müller M, Böhmer SA; et al. (2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. 152 (2): 325–34. PMID 11266449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charest A, Kheifets V, Park J; et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. doi:10.1073/pnas.242741799. PMID 12538861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charest A, Lane K, McMahon K; et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes Chromosomes Cancer. 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Légaré C, Sullivan R (2005). "Expression and localization of c-ros oncogene along the human excurrent duct". Mol. Hum. Reprod. 10 (9): 697–703. doi:10.1093/molehr/gah087. PMID 15235104.
• Biskup C, Böhmer A, Pusch R; et al. (2005). "Visualization of SHP-1-target interaction". J. Cell. Sci. 117 (Pt 21): 5165–78. doi:10.1242/jcs.01397. PMID 15456853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Girish V, Sachdeva N, Minz RW; et al. (2006). "Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype". Indian journal of pathology & microbiology. 48 (3): 325–30. PMID 16761743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)