S100A11
| S100 calcium binding protein A11 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | S100A11 ; MLN70; S100C | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55916 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE S100A11 200660 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
S100 calcium binding protein A11, also known as S100A11, is a human gene.[1]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.[1]
References
Further reading
- Rasmussen HH, van Damme J, Puype M; et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. PMID 1286667.
- Tomasetto C, Régnier C, Moog-Lutz C; et al. (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
- Schäfer BW, Wicki R, Engelkamp D; et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. PMID 7759097.
- Tanaka M, Adzuma K, Iwami M; et al. (1995). "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis". Cancer Lett. 89 (2): 195–200. PMID 7889529.
- Mailliard WS, Haigler HT, Schlaepfer DD (1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I.". J. Biol. Chem. 271 (2): 719–25. PMID 8557678.
- Wicki R, Marenholz I, Mischke D; et al. (1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. PMID 8985590.
- Seemann J, Weber K, Gerke V (1997). "Annexin I targets S100C to early endosomes". FEBS Lett. 413 (1): 185–90. PMID 9287141.
- Inada H, Naka M, Tanaka T; et al. (1999). "Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization". Biochem. Biophys. Res. Commun. 263 (1): 135–8. doi:10.1006/bbrc.1999.1319. PMID 10486266.
- Réty S, Osterloh D, Arié JP; et al. (2000). "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.". Structure. 8 (2): 175–84. PMID 10673436.
- Sakaguchi M, Miyazaki M, Inoue Y; et al. (2000). "Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts". J. Cell Biol. 149 (6): 1193–206. PMID 10851017.
- Deloulme JC, Assard N, Mbele GO; et al. (2001). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
- Ruse M, Lambert A, Robinson N; et al. (2001). "S100A7, S100A10, and S100A11 are transglutaminase substrates". Biochemistry. 40 (10): 3167–73. PMID 11258932.
- Kondo A, Sakaguchi M, Makino E; et al. (2002). "Localization of S100C immunoreactivity in various human tissues". Acta Med. Okayama. 56 (1): 31–4. PMID 11873942.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Bianchi R, Giambanco I, Arcuri C, Donato R (2003). "Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments". Microsc. Res. Tech. 60 (6): 639–51. doi:10.1002/jemt.10305. PMID 12645011.
- Broome AM, Ryan D, Eckert RL (2003). "S100 protein subcellular localization during epidermal differentiation and psoriasis". J. Histochem. Cytochem. 51 (5): 675–85. PMID 12704215.
- Sakaguchi M, Miyazaki M, Takaishi M; et al. (2004). "S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes". J. Cell Biol. 163 (4): 825–35. doi:10.1083/jcb.200304017. PMID 14623863.
- Broome AM, Eckert RL (2004). "Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor". J. Invest. Dermatol. 122 (1): 29–38. doi:10.1046/j.0022-202X.2003.22105.x. PMID 14962086.
- Sakaguchi M, Miyazaki M, Sonegawa H; et al. (2004). "PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11". J. Cell Biol. 164 (7): 979–84. doi:10.1083/jcb.200312041. PMID 15051732.
- Mori M, Shimada H, Gunji Y; et al. (2004). "S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer". Oncol. Rep. 11 (6): 1287–93. PMID 15138568.
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