S100A12

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S100 calcium binding protein A12
File:PBB Protein S100A12 image.jpg
PDB rendering based on 1e8a.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols S100A12 ; MRP6; CGRP; p6; CAAF1; CAGC; ENRAGE
External IDs Template:OMIM5 HomoloGene: 48361
RNA expression pattern
File:PBB GE S100A12 205863 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

S100 calcium binding protein A12, also known as S100A12, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: S100A12 S100 calcium binding protein A12".

Further reading

  • Roth J, Vogl T, Sorg C, Sunderkötter C (2004). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends Immunol. 24 (4): 155–8. PMID 12697438.
  • Guignard F, Mauel J, Markert M (1995). "Identification and characterization of a novel human neutrophil protein related to the S100 family". Biochem. J. 309 ( Pt 2): 395–401. PMID 7626002.
  • Schäfer BW, Wicki R, Engelkamp D; et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. PMID 7759097.
  • Yamamura T, Hitomi J, Nagasaki K; et al. (1996). "Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping". Biochem. Biophys. Res. Commun. 221 (2): 356–60. PMID 8619860.
  • Marti T, Erttmann KD, Gallin MY (1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochem. Biophys. Res. Commun. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID 8619876.
  • Ilg EC, Troxler H, Bürgisser DM; et al. (1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry". Biochem. Biophys. Res. Commun. 225 (1): 146–50. doi:10.1006/bbrc.1996.1144. PMID 8769108.
  • Wicki R, Marenholz I, Mischke D; et al. (1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. PMID 8985590.
  • Hofmann MA, Drury S, Fu C; et al. (1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889–901. PMID 10399917.
  • Moroz OV, Antson AA, Dodson GG; et al. (2000). "Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12". Acta Crystallogr. D Biol. Crystallogr. 56 (Pt 2): 189–91. PMID 10666601.
  • Moroz OV, Antson AA, Murshudov GN; et al. (2001). "The three-dimensional structure of human S100A12". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 1): 20–9. PMID 11134923.
  • Cole AM, Kim YH, Tahk S; et al. (2001). "Calcitermin, a novel antimicrobial peptide isolated from human airway secretions". FEBS Lett. 504 (1–2): 5–10. PMID 11522286.
  • Moroz OV, Antson AA, Dodson EJ; et al. (2002). "The structure of S100A12 in a hexameric form and its proposed role in receptor signalling". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 3): 407–13. PMID 11856825.
  • Strauss GI, Edvinsson L, Larsen FS; et al. (2002). "Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure". Neuropeptides. 35 (3–4): 174–80. doi:10.1054/npep.2001.0861. PMID 11884208.
  • Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. 35 (3–4): 189–95. doi:10.1054/npep.2001.0863. PMID 11884210.
  • Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
  • Ryckman C, Robichaud GA, Roy J; et al. (2002). "HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes". J. Immunol. 169 (6): 3307–13. PMID 12218151.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Foell D, Ichida F, Vogl T; et al. (2003). "S100A12 (EN-RAGE) in monitoring Kawasaki disease". Lancet. 361 (9365): 1270–2. PMID 12699958.
  • Foell D, Kucharzik T, Kraft M; et al. (2003). "Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease". Gut. 52 (6): 847–53. PMID 12740341.

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