SART3

Squamous cell carcinoma antigen recognized by T cells 3
File:PBB Protein SART3 image.jpg PDB rendering based on 2do4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2do4​
Identifiers
Symbols	SART3 ; KIAA0156; MGC138188; RP11-13G14; TIP110; p110(nrb)
External IDs	Template:MGI HomoloGene: 40977
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SART3 209127 s at tn.png
File:PBB GE SART3 209128 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Squamous cell carcinoma antigen recognized by T cells 3, also known as SART3, is a human gene.

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Nagase T, Seki N, Tanaka A; et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang D, Nakao M, Shichijo S; et al. (1999). "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients". Cancer Res. 59 (16): 4056–63. PMID 10463607.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada K, Yamada A, Mine T; et al. (2000). "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen". Jpn. J. Cancer Res. 91 (2): 239–47. PMID 10761712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Tsuda N, Kawano K; et al. (2001). "Expression of tumor-rejection antigens in gynecologic cancers". Jpn. J. Cancer Res. 91 (11): 1177–84. PMID 11092984.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada K, Yamada A, Yang D; et al. (2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". Int. J. Cancer. 93 (5): 623–8. PMID 11477570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasatomi T, Suefuji Y, Matsunaga K; et al. (2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. PMID 11920522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Y, Li J, Kim BO; et al. (2002). "HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110". J. Biol. Chem. 277 (26): 23854–63. doi:10.1074/jbc.M200773200. PMID 11959860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bell M, Schreiner S, Damianov A; et al. (2002). "p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor". EMBO J. 21 (11): 2724–35. doi:10.1093/emboj/21.11.2724. PMID 12032085.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nottrott S, Urlaub H, Lührmann R (2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". EMBO J. 21 (20): 5527–38. PMID 12374753.CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stanĕk D, Rader SD, Klingauf M, Neugebauer KM (2003). "Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies". J. Cell Biol. 160 (4): 505–16. doi:10.1083/jcb.200210087. PMID 12578909.CS1 maint: Multiple names: authors list (link)
• Damianov A, Schreiner S, Bindereif A (2004). "Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP". Mol. Cell. Biol. 24 (4): 1700–8. PMID 14749385.CS1 maint: Multiple names: authors list (link)
• Liu Y, Kim BO, Kao C; et al. (2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". J. Biol. Chem. 279 (21): 21766–73. doi:10.1074/jbc.M314321200. PMID 15031286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Medenbach J, Schreiner S, Liu S; et al. (2004). "Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling". Mol. Cell. Biol. 24 (17): 7392–401. doi:10.1128/MCB.24.17.7392-7401.2004. PMID 15314151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMID 15452143.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)