SDC2

Syndecan 2
Identifiers
Symbols	SDC2 ; HSPG; HSPG1; SYND2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2253
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SDC2 212154 at tn.png
File:PBB GE SDC2 212157 at tn.png
File:PBB GE SDC2 212158 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Syndecan 2, also known as SDC2, is a human gene.

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

Further reading

• Mahley RW, Ji ZS (1999). "Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.". J. Lipid Res. 40 (1): 1–16. PMID 9869645.
• Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7. PMID 1315572.CS1 maint: Multiple names: authors list (link)
• Marynen P, Zhang J, Cassiman JJ; et al. (1989). "Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts". J. Biol. Chem. 264 (12): 7017–24. PMID 2523388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sage H, Vernon RB, Funk SE; et al. (1989). "SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix". J. Cell Biol. 109 (1): 341–56. PMID 2745554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lories V, De Boeck H, David G; et al. (1987). "Heparan sulfate proteoglycans of human lung fibroblasts. Structural heterogeneity of the core proteins of the hydrophobic cell-associated forms". J. Biol. Chem. 262 (2): 854–9. PMID 2948951.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor". Biochemistry. 33 (46): 13918–27. PMID 7524669.
• Bolton P, Powell J, Rutter M; et al. (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1)". Psychiatr. Genet. 5 (2): 51–5. PMID 7551962.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. PMID 7690138.CS1 maint: Multiple names: authors list (link)
• Lyon M, Deakin JA, Mizuno K; et al. (1994). "Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants". J. Biol. Chem. 269 (15): 11216–23. PMID 8157651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• David G, Bai XM, Van der Schueren B; et al. (1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development. 119 (3): 841–54. PMID 8187643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Albini A, Benelli R, Presta M; et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97. PMID 8570206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM; et al. (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system". J. Cell. Sci. 109 ( Pt 7): 1749–57. PMID 8832397.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Christa L, Carnot F, Simon MT; et al. (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002. PMID 8997243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rusnati M, Coltrini D, Oreste P; et al. (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size". J. Biol. Chem. 272 (17): 11313–20. PMID 9111037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh ES, Couchman JR, Woods A (1997). "Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain". Arch. Biochem. Biophys. 344 (1): 67–74. doi:10.1006/abbi.1997.0180. PMID 9244383.CS1 maint: Multiple names: authors list (link)
• Ishikawa-Brush Y, Powell JF, Bolton P; et al. (1997). "Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene". Hum. Mol. Genet. 6 (8): 1241–50. PMID 9259269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang HC, Samaniego F, Nair BC; et al. (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region". AIDS. 11 (12): 1421–31. PMID 9342064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grootjans JJ, Zimmermann P, Reekmans G; et al. (1998). "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13683–8. PMID 9391086.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen AR, Woods DF, Marfatia SM; et al. (1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. PMID 9660868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)