SEMA3A

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
File:PBB Protein SEMA3A image.jpg PDB rendering based on 1q47.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q47​
Identifiers
Symbols	SEMA3A ; SEMAL; Hsema-I; Hsema-III; MGC133243; SEMA1; SEMAD; SEMAIII; SemD; coll-1; sema III
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31358
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SEMA3A 206805 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, also known as SEMA3A, is a human gene.

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

Further reading

• Schmidt EF, Strittmatter SM (2007). "The CRMP family of proteins and their role in Sema3A signaling". Adv. Exp. Med. Biol. 600: 1–11. PMID 17607942.
• Püschel AW, Adams RH, Betz H (1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. PMID 7748561.CS1 maint: Multiple names: authors list (link)
• Kolodkin AL, Matthes DJ, Goodman CS (1994). "The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules". Cell. 75 (7): 1389–99. PMID 8269517.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Chen H, Chédotal A, He Z; et al. (1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. PMID 9331348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi T, Nakamura F, Jin Z; et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi T, Fournier A, Nakamura F; et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99 (1): 59–69. PMID 10520994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castellani V, De Angelis E, Kenwrick S, Rougon G (2003). "Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A". EMBO J. 21 (23): 6348–57. PMID 12456642.CS1 maint: Multiple names: authors list (link)
• Eastwood SL, Law AJ, Everall IP, Harrison PJ (2003). "The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology". Mol. Psychiatry. 8 (2): 148–55. doi:10.1038/sj.mp.4001233. PMID 12610647.CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rieger J, Wick W, Weller M (2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958.CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Serini G, Valdembri D, Zanivan S; et al. (2003). "Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function". Nature. 424 (6947): 391–7. doi:10.1038/nature01784. PMID 12879061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bachelder RE, Lipscomb EA, Lin X; et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells". Cancer Res. 63 (17): 5230–3. PMID 14500350.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Catalano A, Caprari P, Rodilossi S; et al. (2004). "Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation". FASEB J. 18 (2): 358–60. doi:10.1096/fj.03-0513fje. PMID 14656993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bagnard D, Sainturet N, Meyronet D; et al. (2004). "Differential MAP kinases activation during semaphorin3A-induced repulsion or apoptosis of neural progenitor cells". Mol. Cell. Neurosci. 25 (4): 722–31. doi:10.1016/j.mcn.2003.12.007. PMID 15080899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Good PF, Alapat D, Hsu A; et al. (2005). "A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease". J. Neurochem. 91 (3): 716–36. doi:10.1111/j.1471-4159.2004.02766.x. PMID 15485501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marzioni D, Tamagnone L, Capparuccia L; et al. (2005). "Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A". Dev. Dyn. 231 (4): 839–48. doi:10.1002/dvdy.20178. PMID 15517571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu C, Yoshida Y, Livet J; et al. (2005). "Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins". Science. 307 (5707): 265–8. doi:10.1126/science.1105416. PMID 15550623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kashiwagi H, Shiraga M, Kato H; et al. (2005). "Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A". Blood. 106 (3): 913–21. doi:10.1182/blood-2004-10-4092. PMID 15831706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)