SEPT6
| Septin 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SEPT6 ; KIAA0128; MGC16619; MGC20339; SEP2 | ||||||||||
| External IDs | Template:MGI HomoloGene: 62617 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SEPT6 212413 at tn.png | |||||||||||
| File:PBB GE SEPT6 212414 s at tn.png | |||||||||||
| File:PBB GE SEPT6 213666 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Septin 6, also known as SEPT6, is a human gene.[1]
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.[1]
References
Further reading
- Nagase T, Seki N, Tanaka A; et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.
- Xue J, Wang X, Malladi CS; et al. (2000). "Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase". J. Biol. Chem. 275 (14): 10047–56. PMID 10744683.
- Kinoshita A, Noda M, Kinoshita M (2000). "Differential localization of septins in the mouse brain". J. Comp. Neurol. 428 (2): 223–39. PMID 11064363.
- Ono R, Taki T, Taketani T; et al. (2002). "SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24". Cancer Res. 62 (2): 333–7. PMID 11809673.
- Slater DJ, Hilgenfeld E, Rappaport EF; et al. (2002). "MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site". Oncogene. 21 (30): 4706–14. doi:10.1038/sj.onc.1205572. PMID 12096348.
- Surka MC, Tsang CW, Trimble WS (2003). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Mol. Biol. Cell. 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMID 12388755.
- Sheffield PJ, Oliver CJ, Kremer BE; et al. (2003). "Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments". J. Biol. Chem. 278 (5): 3483–8. doi:10.1074/jbc.M209701200. PMID 12446710.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Vega IE, Hsu SC (2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells". Neuroreport. 14 (1): 31–7. doi:10.1097/01.wnr.0000050304.92401.50. PMID 12544826.
- Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Koshelev YA, Kiselev SL, Georgiev GP (2004). "Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro". Dokl. Biochem. Biophys. 391: 195–7. PMID 14531065.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kadkol SS, Bruno A, Oh S; et al. (2006). "MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia". Cancer Genet. Cytogenet. 168 (2): 162–7. doi:10.1016/j.cancergencyto.2006.02.020. PMID 16843108.
- Low C, Macara IG (2006). "Structural analysis of septin 2, 6, and 7 complexes". J. Biol. Chem. 281 (41): 30697–706. doi:10.1074/jbc.M605179200. PMID 16914550.
- Kim CS, Seol SK, Song OK; et al. (2007). "An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication". J. Virol. 81 (8): 3852–65. doi:10.1128/JVI.01311-06. PMID 17229681.
- Sirajuddin M, Farkasovsky M, Hauer F; et al. (2007). "Structural insight into filament formation by mammalian septins". Nature. 449 (7160): 311–5. doi:10.1038/nature06052. PMID 17637674.
- Kremer BE, Adang LA, Macara IG (2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7". Cell. 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMID 17803907.
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