SF3A2
| Splicing factor 3a, subunit 2, 66kDa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SF3A2 ; PRP11; PRPF11; SAP62; SF3a66 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 5184 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SF3A2 37462 i at tn.png | |||||||||||
| File:PBB GE SF3A2 209381 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Splicing factor 3a, subunit 2, 66kDa, also known as SF3A2, is a human gene.[1]
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.[1]
References
Further reading
- Chiara MD, Champion-Arnaud P, Buvoli M; et al. (1994). "Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6403–7. PMID 8022796.
- Bennett M, Reed R (1993). "Correspondence between a mammalian spliceosome component and an essential yeast splicing factor". Science. 262 (5130): 105–8. PMID 8211113.
- Dresser DW, Hacker A, Lovell-Badge R, Guerrier D (1996). "The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous". Hum. Mol. Genet. 4 (9): 1613–8. PMID 8541848.
- Rain JC, Tartakoff AM, Krämer A, Legrain P (1996). "Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution". RNA. 2 (6): 535–50. PMID 8718683.
- Hong W, Bennett M, Xiao Y; et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. PMID 9016565.
- Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles". Biochem. J. 332 ( Pt 1): 135–44. PMID 9576861.
- Yan D, Perriman R, Igel H; et al. (1998). "CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif". Mol. Cell. Biol. 18 (9): 5000–9. PMID 9710584.
- Neubauer G, King A, Rappsilber J; et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
- Krämer A, Grüter P, Gröning K, Kastner B (1999). "Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP". J. Cell Biol. 145 (7): 1355–68. PMID 10385517.
- Das R, Zhou Z, Reed R (2000). "Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.". Mol. Cell. 5 (5): 779–87. PMID 10882114.
- Will CL, Schneider C, MacMillan AM; et al. (2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site". EMBO J. 20 (16): 4536–46. doi:10.1093/emboj/20.16.4536. PMID 11500380.
- Nesic D, Krämer A (2001). "Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation". Mol. Cell. Biol. 21 (19): 6406–17. PMID 11533230.
- Dresser DW, Jamin SP, Atkins CJ, Guerrier D (2001). "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH". Gene. 277 (1–2): 163–73. PMID 11602354.
- Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMID 11991638.
- Will CL, Urlaub H, Achsel T; et al. (2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. PMID 12234937.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Takenaka K, Nakagawa H, Miyamoto S, Miki H (2005). "The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein". Biochem. J. 382 (Pt 1): 223–30. doi:10.1042/BJ20040521. PMID 15142036.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
- Nesic D, Tanackovic G, Krämer A (2005). "A role for Cajal bodies in the final steps of U2 snRNP biogenesis". J. Cell. Sci. 117 (Pt 19): 4423–33. doi:10.1242/jcs.01308. PMID 15316075.
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