SFRP4

Secreted frizzled-related protein 4
Identifiers
Symbols	SFRP4 ; FRP-4; FRPHE; MGC26498
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2267
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SFRP4 204051 s at tn.png
File:PBB GE SFRP4 204052 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Secreted frizzled-related protein 4, also known as SFRP4, is a human gene.

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.

Further reading

• Rattner A, Hsieh JC, Smallwood PM; et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. PMID 9096311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolf V, Ke G, Dharmarajan AM; et al. (1998). "DDC-4, an apoptosis-associated gene, is a secreted frizzled relative". FEBS Lett. 417 (3): 385–9. PMID 9409757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abu-Jawdeh G, Comella N, Tomita Y; et al. (1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Lab. Invest. 79 (4): 439–47. PMID 10211996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schumann H, Holtz J, Zerkowski HR, Hatzfeld M (2000). "Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression". Cardiovasc. Res. 45 (3): 720–8. PMID 10728394.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berndt T, Craig TA, Bowe AE; et al. (2003). "Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent". J. Clin. Invest. 112 (5): 785–94. doi:10.1172/JCI200318563. PMID 12952927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wissmann C, Wild PJ, Kaiser S; et al. (2003). "WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer". J. Pathol. 201 (2): 204–12. doi:10.1002/path.1449. PMID 14517837.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Horvath LG, Henshall SM, Kench JG; et al. (2004). "Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro". Clin. Cancer Res. 10 (2): 615–25. PMID 14760084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahn J, Chung KS, Kim DU; et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He B, Lee AY, Dadfarmay S; et al. (2005). "Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells". Cancer Res. 65 (3): 743–8. PMID 15705870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berndt TJ, Bielesz B, Craig TA; et al. (2006). "Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells". Pflugers Arch. 451 (4): 579–87. doi:10.1007/s00424-005-1495-2. PMID 16151791.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Han Q, Zhao W, Bentel J; et al. (2006). "Expression of sFRP-4 and beta-catenin in human colorectal carcinoma". Cancer Lett. 231 (1): 129–37. doi:10.1016/j.canlet.2005.01.026. PMID 16356838.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Urakami S, Shiina H, Enokida H; et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Horvath LG, Lelliott JE, Kench JG; et al. (2007). "Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer". Prostate. 67 (10): 1081–90. doi:10.1002/pros.20607. PMID 17476687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)