SH2B1

SH2B adaptor protein 1
File:PBB Protein SH2B1 image.jpg PDB rendering based on 2hdv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2hdv​, 2hdx​
Identifiers
Symbols	SH2B1 ; DKFZp547G1110; FLJ30542; SH2-B; SH2B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32122
Gene ontology Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SH2B1 209322 s at tn.png
File:PBB GE SH2B1 40149 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SH2B adaptor protein 1, also known as SH2B1, is a human gene.

Further reading

• Rui L, Mathews LS, Hotta K; et al. (1997). "Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling". Mol. Cell. Biol. 17 (11): 6633–44. PMID 9343427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kotani K, Wilden P, Pillay TS (1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase". Biochem. J. 335 ( Pt 1): 103–9. PMID 9742218.CS1 maint: Multiple names: authors list (link)
• Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. PMID 9856458.CS1 maint: Multiple names: authors list (link)
• Nelms K, O'Neill TJ, Li S; et al. (2000). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain". Mamm. Genome. 10 (12): 1160–7. PMID 10594240.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koch A, Mancini A, Stefan M; et al. (2000). "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop". FEBS Lett. 469 (1): 72–6. PMID 10708759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rui L, Gunter DR, Herrington J, Carter-Su C (2000). "Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta". Mol. Cell. Biol. 20 (9): 3168–77. PMID 10757801.CS1 maint: Multiple names: authors list (link)
• O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases". J. Biol. Chem. 277 (10): 8673–81. doi:10.1074/jbc.M109165200. PMID 11751854.CS1 maint: Multiple names: authors list (link)
• Kong M, Wang CS, Donoghue DJ (2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation". J. Biol. Chem. 277 (18): 15962–70. doi:10.1074/jbc.M102777200. PMID 11827956.CS1 maint: Multiple names: authors list (link)
• Ohtsuka S, Takaki S, Iseki M; et al. (2002). "SH2-B is required for both male and female reproduction". Mol. Cell. Biol. 22 (9): 3066–77. PMID 11940664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie S, Lin H, Sun T, Arlinghaus RB (2002). "Jak2 is involved in c-Myc induction by Bcr-Abl". Oncogene. 21 (47): 7137–46. doi:10.1038/sj.onc.1205942. PMID 12370803.CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Brien KB, Argetsinger LS, Diakonova M, Carter-Su C (2003). "YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling". J. Biol. Chem. 278 (14): 11970–8. doi:10.1074/jbc.M210765200. PMID 12551917.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishi M, Werner ED, Oh BC; et al. (2005). "Kinase activation through dimerization by human SH2-B". Mol. Cell. Biol. 25 (7): 2607–21. doi:10.1128/MCB.25.7.2607-2621.2005. PMID 15767667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donatello S, Fiorino A, Degl'Innocenti D; et al. (2007). "SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling". Oncogene. 26 (45): 6546–59. doi:10.1038/sj.onc.1210480. PMID 17471236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)