SHC3

SHC (Src homology 2 domain containing) transforming protein 3
Identifiers
Symbols	SHC3 ; N-Shc; NSHC; SHCC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7536
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SHC3 206330 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SHC (Src homology 2 domain containing) transforming protein 3, also known as SHC3, is a human gene.

Further reading

• O'Bryan JP, Songyang Z, Cantley L; et al. (1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 2729–34. PMID 8610109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pelicci G, Dente L, De Giuseppe A; et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Sanokawa R, Sasaki Y; et al. (1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Menegon A, Leoni C, Benfenati F, Valtorta F (1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochem. Biophys. Res. Commun. 238 (3): 800–5. doi:10.1006/bbrc.1997.7393. PMID 9325171.CS1 maint: Multiple names: authors list (link)
• Wang JF, Ganju RK, Liu ZY; et al. (1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. 90 (9): 3507–15. PMID 9345034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. 273 (12): 6960–7. PMID 9507002.CS1 maint: Multiple names: authors list (link)
• Cook KK, Fadool DA (2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase". J. Biol. Chem. 277 (15): 13268–80. doi:10.1074/jbc.M108898200. PMID 11812778.
• Tarr PE, Roncarati R, Pelicci G; et al. (2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". J. Biol. Chem. 277 (19): 16798–804. doi:10.1074/jbc.M110286200. PMID 11877420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu HY, Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
• Miyake I, Hakomori Y, Shinohara A; et al. (2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines". Oncogene. 21 (38): 5823–34. doi:10.1038/sj.onc.1205735. PMID 12185581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pelicci G, Troglio F, Bodini A; et al. (2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway". Mol. Cell. Biol. 22 (20): 7351–63. PMID 12242309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Komiya M, Sone K; et al. (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. 22 (24): 8721–34. PMID 12446789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyake I, Hakomori Y, Misu Y; et al. (2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene. 24 (19): 3206–15. doi:10.1038/sj.onc.1208523. PMID 15735675.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magrassi L, Conti L, Lanterna A; et al. (2005). "Shc3 affects human high-grade astrocytomas survival". Oncogene. 24 (33): 5198–206. doi:10.1038/sj.onc.1208708. PMID 15870690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Falco V, Guarino V, Malorni L; et al. (2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors". Oncogene. 24 (41): 6303–13. doi:10.1038/sj.onc.1208776. PMID 15940252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toschi E, Bacigalupo I, Strippoli R; et al. (2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway". Mol. Biol. Cell. 17 (4): 1985–94. doi:10.1091/mbc.E05-08-0717. PMID 16436505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li MD, Sun D, Lou XY; et al. (2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence". Mol. Psychiatry. 12 (5): 462–73. doi:10.1038/sj.mp.4001933. PMID 17179996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)