SLBP

Stem-loop (histone) binding protein
Identifiers
Symbols	SLBP ; HBP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31389
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLBP 206052 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Stem-loop (histone) binding protein, also known as SLBP, is a human gene.

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.

Further reading

• McCombie WR, Martin-Gallardo A, Gocayne JD; et al. (1993). "Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3". Nat. Genet. 1 (5): 348–53. doi:10.1038/ng0892-348. PMID 1338771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanson RJ, Sun J, Willis DG, Marzluff WF (1996). "Efficient extraction and partial purification of the polyribosome-associated stem-loop binding protein bound to the 3' end of histone mRNA". Biochemistry. 35 (7): 2146–56. doi:10.1021/bi9521856. PMID 8652556.CS1 maint: Multiple names: authors list (link)
• Wang ZF, Whitfield ML, Ingledue TC; et al. (1997). "The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing". Genes Dev. 10 (23): 3028–40. PMID 8957003.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin F, Schaller A, Eglite S; et al. (1997). "The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein". EMBO J. 16 (4): 769–78. doi:10.1093/emboj/16.4.769. PMID 9049306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dominski Z, Zheng LX, Sanchez R, Marzluff WF (1999). "Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA". Mol. Cell. Biol. 19 (5): 3561–70. PMID 10207079.CS1 maint: Multiple names: authors list (link)
• Whitfield ML, Zheng LX, Baldwin A; et al. (2000). "Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms". Mol. Cell. Biol. 20 (12): 4188–98. PMID 10825184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato M, Miyazawa K, Kitamura N (2001). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.CS1 maint: Multiple names: authors list (link)
• Dominski Z, Erkmann JA, Greenland JA, Marzluff WF (2001). "Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing". Mol. Cell. Biol. 21 (6): 2008–17. doi:10.1128/MCB.21.6.2008-2017.2001. PMID 11238936.CS1 maint: Multiple names: authors list (link)
• Dominski Z, Erkmann JA, Yang X; et al. (2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes Dev. 16 (1): 58–71. doi:10.1101/gad.932302. PMID 11782445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allard P, Champigny MJ, Skoggard S; et al. (2003). "Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo". J. Cell. Sci. 115 (Pt 23): 4577–86. PMID 12415002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zheng L, Dominski Z, Yang XC; et al. (2003). "Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase". Mol. Cell. Biol. 23 (5): 1590–601. PMID 12588979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dominski Z, Yang XC, Kaygun H; et al. (2003). "A 3' exonuclease that specifically interacts with the 3' end of histone mRNA". Mol. Cell. 12 (2): 295–305. PMID 14536070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao X, McKillop-Smith S, Müller B (2005). "The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells". J. Cell. Sci. 117 (Pt 25): 6043–51. doi:10.1242/jcs.01523. PMID 15546920.CS1 maint: Multiple names: authors list (link)
• Erkmann JA, Wagner EJ, Dong J; et al. (2005). "Nuclear import of the stem-loop binding protein and localization during the cell cycle". Mol. Biol. Cell. 16 (6): 2960–71. doi:10.1091/mbc.E04-11-1023. PMID 15829567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wagner EJ, Berkow A, Marzluff WF (2005). "Expression of an RNAi-resistant SLBP restores proper S-phase progression". Biochem. Soc. Trans. 33 (Pt 3): 471–3. doi:10.1042/BST0330471. PMID 15916543.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borchers CH, Thapar R, Petrotchenko EV; et al. (2006). "Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding". Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3094–9. doi:10.1073/pnas.0511289103. PMID 16492733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)