SLURP1

Secreted LY6/PLAUR domain containing 1
Identifiers
Symbols	SLURP1 ; ARS; ANUP; ArsB; LY6LS; MDM
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10710
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLURP1 214536 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Secreted LY6/PLAUR domain containing 1, also known as SLURP1, is a human gene.

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.

Further reading

• Ridge RJ, Sloane NH (1996). "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes". Cytokine. 8 (1): 1–5. doi:10.1006/cyto.1996.0001. PMID 8742060.
• Fischer J, Bouadjar B, Heilig R; et al. (1999). "Genetic linkage of Meleda disease to chromosome 8qter". Eur. J. Hum. Genet. 6 (6): 542–7. doi:10.1038/sj.ejhg.5200254. PMID 9887370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adermann K, Wattler F, Wattler S; et al. (1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Sci. 8 (4): 810–9. PMID 10211827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fischer J, Bouadjar B, Heilig R; et al. (2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Hum. Mol. Genet. 10 (8): 875–80. PMID 11285253.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eckl KM, Stevens HP, Lestringant GG; et al. (2003). "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates". Hum. Genet. 112 (1): 50–6. doi:10.1007/s00439-002-0838-8. PMID 12483299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marrakchi S, Audebert S, Bouadjar B; et al. (2003). "Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda". J. Invest. Dermatol. 120 (3): 351–5. doi:10.1046/j.1523-1747.2003.12062.x. PMID 12603845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu G, Yildirim M, Baysal V; et al. (2003). "A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect". J. Invest. Dermatol. 120 (6): 967–9. doi:10.1046/j.1523-1747.2003.12248.x. PMID 12787122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chimienti F, Hogg RC, Plantard L; et al. (2004). "Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda". Hum. Mol. Genet. 12 (22): 3017–24. doi:10.1093/hmg/ddg320. PMID 14506129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charfeddine C, Mokni M, Ben Mousli R; et al. (2004). "A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia". Br. J. Dermatol. 149 (6): 1108–15. PMID 14674887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mastrangeli R, Donini S, Kelton CA; et al. (2004). "ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda". European journal of dermatology : EJD. 13 (6): 560–70. PMID 14721776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mokni M, Charfeddine C, Ben Mously R; et al. (2004). "Heterozygous manifestations in female carriers of Mal de Meleda". Clin. Genet. 65 (3): 244–6. PMID 14756676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chao SC, Lai FJ, Yang MH, Lee JY (2006). "Mal de Meleda in a taiwanese". J. Formos. Med. Assoc. 104 (4): 276–8. PMID 15909066.CS1 maint: Multiple names: authors list (link)
• Arredondo J, Chernyavsky AI, Webber RJ, Grando SA (2006). "Biological effects of SLURP-1 on human keratinocytes". J. Invest. Dermatol. 125 (6): 1236–41. doi:10.1111/j.0022-202X.2005.23973.x. PMID 16354194.CS1 maint: Multiple names: authors list (link)
• Arredondo J, Chernyavsky AI, Grando SA (2007). "Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells". Biochem. Pharmacol. 74 (8): 1315–9. doi:10.1016/j.bcp.2007.06.026. PMID 17643396.CS1 maint: Multiple names: authors list (link)