SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
File:PBB Protein SMARCA2 image.jpg PDB rendering based on 2dat.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dat​
Identifiers
Symbols	SMARCA2 ; SWI2; BAF190; BRM; FLJ36757; MGC74511; SNF2; SNF2L2; SNF2LA; Sth1p; hBRM; hSNF2a
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2308
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SMARCA2 206542 s at tn.png
File:PBB GE SMARCA2 206544 x at tn.png
File:PBB GE SMARCA2 217707 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, also known as SMARCA2, is a human gene.

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Further reading

• Aves SJ, Hindley J, Phear GA, Tongue N (1995). "A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains". Mol. Gen. Genet. 248 (4): 491–8. PMID 7565614.CS1 maint: Multiple names: authors list (link)
• Muchardt C, Yaniv M, Mattei MG (1994). "Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization". Mamm. Genome. 5 (4): 241–3. PMID 8012116.CS1 maint: Multiple names: authors list (link)
• Chiba H, Muramatsu M, Nomoto A, Kato H (1994). "Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor". Nucleic Acids Res. 22 (10): 1815–20. PMID 8208605.CS1 maint: Multiple names: authors list (link)
• Muchardt C, Yaniv M (1993). "A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor". EMBO J. 12 (11): 4279–90. PMID 8223438.
• Muchardt C, Reyes JC, Bourachot B; et al. (1996). "The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis". EMBO J. 15 (13): 3394–402. PMID 8670841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang W, Xue Y, Zhou S; et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. PMID 8804307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang W, Côté J, Xue Y; et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMID 8895581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichinose H, Garnier JM, Chambon P, Losson R (1997). "Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2". Gene. 188 (1): 95–100. PMID 9099865.CS1 maint: Multiple names: authors list (link)
• Cho H, Orphanides G, Sun X; et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thaete C, Brett D, Monaghan P; et al. (1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Hum. Mol. Genet. 8 (4): 585–91. PMID 10072425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell. 3 (2): 247–53. PMID 10078207.CS1 maint: Multiple names: authors list (link)
• Lee DW, Zhang K, Ning ZQ; et al. (2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res. 60 (13): 3612–22. PMID 10910076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Phelan ML, Schnitzler GR, Kingston RE (2000). "Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases". Mol. Cell. Biol. 20 (17): 6380–9. PMID 10938115.CS1 maint: Multiple names: authors list (link)
• Xue Y, Canman JC, Lee CS; et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMID 11078522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Machida Y, Murai K, Miyake K, Iijima S (2001). "Expression of chromatin remodeling factors during neural differentiation". J. Biochem. 129 (1): 43–9. PMID 11134956.CS1 maint: Multiple names: authors list (link)
• de la Serna IL, Carlson KA, Imbalzano AN (2001). "Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation". Nat. Genet. 27 (2): 187–90. doi:10.1038/84826. PMID 11175787.CS1 maint: Multiple names: authors list (link)
• Ruhf ML, Braun A, Papoulas O; et al. (2001). "The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes". Development. 128 (8): 1429–41. PMID 11262242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strobeck MW, Reisman DN, Gunawardena RW; et al. (2002). "Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling". J. Biol. Chem. 277 (7): 4782–9. doi:10.1074/jbc.M109532200. PMID 11719516.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato H, Tjernberg A, Zhang W; et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizutani T, Ito T, Nishina M; et al. (2002). "Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex". J. Biol. Chem. 277 (18): 15859–64. doi:10.1074/jbc.M112421200. PMID 11850427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)