SNX17

Sorting nexin 17
Identifiers
Symbols	SNX17 ; KIAA0064
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8838
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SNX17 200991 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sorting nexin 17, also known as SNX17, is a human gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.

Further reading

• Nomura N, Nagase T, Miyajima N; et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. PMID 7584044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.CS1 maint: Multiple names: authors list (link)
• Florian V, Schlüter T, Bohnensack R (2001). "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): 1045–50. doi:10.1006/bbrc.2001.4467. PMID 11237770.CS1 maint: Multiple names: authors list (link)
• Teasdale RD, Loci D, Houghton F; et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. PMID 11485546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stockinger W, Sailler B, Strasser V; et al. (2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. PMID 12169628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burden JJ, Sun XM, García AB, Soutar AK (2004). "Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17". J. Biol. Chem. 279 (16): 16237–45. doi:10.1074/jbc.M313689200. PMID 14739284.CS1 maint: Multiple names: authors list (link)
• Williams R, Schlüter T, Roberts MS; et al. (2005). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Mol. Biol. Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMID 15121882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knauth P, Schlüter T, Czubayko M; et al. (2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Kerkhof P, Lee J, McCormick L; et al. (2006). "Sorting nexin 17 facilitates LRP recycling in the early endosome". EMBO J. 24 (16): 2851–61. doi:10.1038/sj.emboj.7600756. PMID 16052210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Czubayko M, Knauth P, Schlüter T; et al. (2006). "Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1". Biochem. Biophys. Res. Commun. 345 (3): 1264–72. doi:10.1016/j.bbrc.2006.04.129. PMID 16712798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)