SNX9
| Sorting nexin 9 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SNX9 ; SDP1; MST155; MSTP155; SH3PX1; SH3PXD3A; WISP | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 49454 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SNX9 gnf1h00218 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Sorting nexin 9, also known as SNX9, is a human gene.[1]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.[1]
References
Further reading
- Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. PMID 10531379.
- Teasdale RD, Loci D, Houghton F; et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. PMID 11485546.
- Lin Q, Lo CG, Cerione RA, Yang W (2002). "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (12): 10134–8. doi:10.1074/jbc. M110329200 Check
|doi=value (help). PMID 11799118. - Lundmark R, Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2". Biochem. J. 362 (Pt 3): 597–607. PMID 11879186.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Lundmark R, Carlsson SR (2004). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47): 46772–81. doi:10.1074/jbc. M307334200 Check
|doi=value (help). PMID 12952949. - Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc. M309909200 Check
|doi=value (help). PMID 14679214. - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
- Lundmark R, Carlsson SR (2004). "Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9". J. Biol. Chem. 279 (41): 42694–702. doi:10.1074/jbc. M407430200 Check
|doi=value (help). PMID 15299020. - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Soulet F, Yarar D, Leonard M, Schmid SL (2005). "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis". Mol. Biol. Cell. 16 (4): 2058–67. doi:10.1091/mbc. E04-11-1016 Check
|doi=value (help). PMID 15703209. - Yeow-Fong L, Lim L, Manser E (2005). "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1". FEBS Lett. 579 (22): 5040–8. doi:10.1016/j.febslet.2005.07.093. PMID 16137687.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Childress C, Lin Q, Yang W (2006). "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2". Biochem. J. 394 (Pt 3): 693–8. doi:10.1042/BJ20050576. PMID 16316319.
- Marchès O, Batchelor M, Shaw RK; et al. (2006). "EspF of enteropathogenic Escherichia coli binds sorting nexin 9". J. Bacteriol. 188 (8): 3110–5. doi:10.1128/JB.188.8.3110-3115.2006. PMID 16585770.
- Schmid EM, Ford MG, Burtey A; et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMID 16903783.
- Badour K, McGavin MK, Zhang J; et al. (2007). "Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells". Proc. Natl. Acad. Sci. U.S.A. 104 (5): 1593–8. doi:10.1073/pnas.0610543104. PMID 17242350.
- Yarar D, Waterman-Storer CM, Schmid SL (2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev. Cell. 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109.
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