SPDEF

SAM pointed domain containing ets transcription factor
File:PBB Protein SPDEF image.jpg PDB rendering based on 1yo5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1yo5​, 2dkx​
Identifiers
Symbols	SPDEF ; PDEF; RP11-375E1__A.3; bA375E1.3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8231
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SPDEF 213441 x at tn.png
File:PBB GE SPDEF 214404 x at tn.png
File:PBB GE SPDEF 220192 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SAM pointed domain containing ets transcription factor, also known as SPDEF, is a human gene.

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]

Further reading

• Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions". Comparative biochemistry and physiology. A, Comparative physiology. 53 (3): 285–9. PMID 2437.
• Johannessen JV, Finseth I (1983). "Electron micrographs in five minutes". Ultrastructural pathology. 4 (1): 97–100. PMID 6857767.
• Oettgen P, Finger E, Sun Z; et al. (2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J. Biol. Chem. 275 (2): 1216–25. PMID 10625666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada N, Tamai Y, Miyamoto H, Nozaki M (2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member". Gene. 241 (2): 267–74. PMID 10675039.CS1 maint: Multiple names: authors list (link)
• Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. 62 (2): 338–40. PMID 11809674.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thompson HG, Harris JW, Wold BJ; et al. (2003). "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells". Oncogene. 22 (15): 2322–33. doi:10.1038/sj.onc.1206325. PMID 12700667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feldman RJ, Sementchenko VI, Gayed M; et al. (2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression". Cancer Res. 63 (15): 4626–31. PMID 12907642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ghadersohi A, Odunsi K, Lele S; et al. (2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules". Oncol. Rep. 11 (2): 453–8. PMID 14719083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673.
• Wang Y, Feng L, Said M; et al. (2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site". Biochemistry. 44 (19): 7095–106. doi:10.1021/bi047352t. PMID 15882048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fowler M, Borazanci E, McGhee L; et al. (2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". J. Cell. Biochem. 97 (1): 1–17. doi:10.1002/jcb.20664. PMID 16237704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gunawardane RN, Sgroi DC, Wrobel CN; et al. (2006). "Novel role for PDEF in epithelial cell migration and invasion". Cancer Res. 65 (24): 11572–80. doi:10.1158/0008-5472.CAN-05-1196. PMID 16357167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodabaugh KJ, Mhawech-Fauceglia P, Groth J; et al. (2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors". Int. J. Gynecol. Pathol. 26 (1): 10–5. doi:10.1097/01.pgp.0000225386.41244.bd. PMID 17197890.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park KS, Korfhagen TR, Bruno MD; et al. (2007). "SPDEF regulates goblet cell hyperplasia in the airway epithelium". J. Clin. Invest. 117 (4): 978–88. doi:10.1172/JCI29176. PMID 17347682.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)