SPINT2
| Serine peptidase inhibitor, Kunitz type, 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SPINT2 ; HAI-2; HAI2; Kop; PB | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7955 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SPINT2 210715 s at tn.png | |||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Serine peptidase inhibitor, Kunitz type, 2, also known as SPINT2, is a human gene.[1]
References
Further reading
- Morelle W, Capon C, Balduyck M; et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. PMID 7513643.
- Mizon C, Balduyck M, Albani D; et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". J. Immunol. Methods. 190 (1): 61–70. PMID 8601712.
- Gress TM, Müller-Pillasch F, Geng M; et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
- Shimomura T, Denda K, Kitamura A; et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (10): 6370–6. PMID 9045658.
- Marlor CW, Delaria KA, Davis G; et al. (1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". J. Biol. Chem. 272 (18): 12202–8. PMID 9115294.
- Kawaguchi T, Qin L, Shimomura T; et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (44): 27558–64. PMID 9346890.
- Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". Biochem. J. 328 ( Pt 1): 185–91. PMID 9359851.
- Müller-Pillasch F, Wallrapp C, Bartels K; et al. (1998). "Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer". Biochim. Biophys. Acta. 1395 (1): 88–95. PMID 9434156.
- Kataoka H, Shimomura T, Kawaguchi T; et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.
- Itoh H, Kataoka H, Yamauchi M; et al. (2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochem. Biophys. Res. Commun. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
- Suzuki M, Kobayashi H, Fujie M; et al. (2002). "Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells". J. Biol. Chem. 277 (10): 8022–32. doi:10.1074/jbc.M108545200. PMID 11777908.
- Kobayashi H, Suzuki M, Kanayama N; et al. (2002). "Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade". Eur. J. Biochem. 269 (16): 3945–57. PMID 12180971.
- Mizon C, Piva F, Queyrel V; et al. (2003). "Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases". Clin. Chem. Lab. Med. 40 (6): 579–86. PMID 12211652.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Isogai R, Matsukura A, Aragane Y; et al. (2003). "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis". Arch. Dermatol. Res. 294 (9): 387–92. doi:10.1007/s00403-002-0336-9. PMID 12522575.
- Yamauchi M, Itoh H, Naganuma S; et al. (2003). "Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis". Biol. Chem. 383 (12): 1953–7. PMID 12553733.
- Suzuki M, Kobayashi H, Tanaka Y; et al. (2003). "Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin". Int. J. Cancer. 104 (3): 289–302. doi:10.1002/ijc.10950. PMID 12569552.
- Suzuki M, Kobayashi H, Tanaka Y; et al. (2003). "Bikunin target genes in ovarian cancer cells identified by microarray analysis". J. Biol. Chem. 278 (17): 14640–6. doi:10.1074/jbc.M300239200. PMID 12571229.
- Schuster JM, Longo M, Nelson PS (2003). "Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment". J. Neurooncol. 64 (3): 219–25. PMID 14558597.
- Fukai K, Yokosuka O, Chiba T; et al. (2004). "Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma". Cancer Res. 63 (24): 8674–9. PMID 14695180.
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