SS18

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Synovial sarcoma translocation, chromosome 18
Identifiers
Symbols SS18 ; MGC116875; SSXT; SYT
External IDs Template:OMIM5 Template:MGI HomoloGene38080
RNA expression pattern
File:PBB GE SS18 202816 s at tn.png
File:PBB GE SS18 202817 s at tn.png
File:PBB GE SS18 209954 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Synovial sarcoma translocation, chromosome 18, also known as SS18, is a human gene.[1]


References

  1. "Entrez Gene: SS18 synovial sarcoma translocation, chromosome 18".

Further reading

  • Fligman I, Lonardo F, Jhanwar SC; et al. (1996). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". Am. J. Pathol. 147 (6): 1592–9. PMID 7495284.
  • Clark J, Rocques PJ, Crew AJ; et al. (1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nat. Genet. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320.
  • Shipley JM, Clark J, Crew AJ; et al. (1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene. 9 (5): 1447–53. PMID 8152806.
  • Brett D, Whitehouse S, Antonson P; et al. (1998). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Hum. Mol. Genet. 6 (9): 1559–64. PMID 9285794.
  • Thaete C, Brett D, Monaghan P; et al. (1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Hum. Mol. Genet. 8 (4): 585–91. PMID 10072425.
  • Eid JE, Kung AL, Scully R, Livingston DM (2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. PMID 11030627.
  • Tamborini E, Agus V, Mezzelani A; et al. (2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". Br. J. Cancer. 84 (8): 1087–94. doi:10.1054/bjoc.2000.1710. PMID 11308259.
  • Brodin B, Haslam K, Yang K; et al. (2001). "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression". Gene. 268 (1–2): 173–82. PMID 11368913.
  • de Bruijn DR, dos Santos NR, Thijssen J; et al. (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.
  • Suzuki H, Fukunishi Y, Kagawa I; et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
  • Kato H, Tjernberg A, Zhang W; et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
  • Yang K, Lui WO, Xie Y; et al. (2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Imabayashi H, Mori T, Gojo S; et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.
  • Perani M, Ingram CJ, Cooper CS; et al. (2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Iwasaki T, Koibuchi N, Chin WW (2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology. 146 (9): 3892–9. doi:10.1210/en.2004-1513. PMID 15919756.
  • Fernebro J, Francis P, Edén P; et al. (2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". Int. J. Cancer. 118 (5): 1165–72. doi:10.1002/ijc.21475. PMID 16152617.
  • Perani M, Antonson P, Hamoudi R; et al. (2006). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". J. Biol. Chem. 280 (52): 42863–76. doi:10.1074/jbc.M502963200. PMID 16227627.
  • Sun Y, Gao D, Liu Y; et al. (2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene. 25 (7): 1042–52. doi:10.1038/sj.onc.1209143. PMID 16247461.

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