ST3GAL3
| ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | ST3GAL3 ; ST3GALII; SIAT6; ST3Gal III; ST3GalIII; ST3N | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7539 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a human gene.[1]
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Multiple transcript variants encoding several different isoforms have been found for this gene.[1]
References
Further reading
- Kalyanaraman VS, Rodriguez V, Veronese F; et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. PMID 2187500.
- Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. PMID 2541446.
- Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. PMID 2542563.
- Kozarsky K, Penman M, Basiripour L; et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
- Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. PMID 2829950.
- Kitagawa H, Paulson JC (1994). "Differential expression of five sialyltransferase genes in human tissues". J. Biol. Chem. 269 (27): 17872–8. PMID 8027041.
- Kitagawa H, Paulson JC (1993). "Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase". Biochem. Biophys. Res. Commun. 194 (1): 375–82. doi:10.1006/bbrc.1993.1830. PMID 8333853.
- Burger PC, Lötscher M, Streiff M; et al. (1998). "Immunocytochemical localization of alpha2,3(N)-sialyltransferase (ST3Gal III) in cell lines and rat kidney tissue sections: evidence for golgi and post-golgi localization". Glycobiology. 8 (3): 245–57. PMID 9451034.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Taniguchi A, Morishima T, Tsujita Y; et al. (2003). "Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene". Biochem. Biophys. Res. Commun. 300 (2): 570–6. PMID 12504121.
- Taniguchi A, Saito K, Kubota T, Matsumoto K (2003). "Characterization of the promoter region of the human Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase III (hST3Gal III) gene". Biochim. Biophys. Acta. 1626 (1–3): 92–6. PMID 12697334.
- Saito S, Aoki H, Ito A; et al. (2003). "Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase". J. Biol. Chem. 278 (29): 26474–9. doi:10.1074/jbc.M213223200. PMID 12716912.
- Grahn A, Barkhordar GS, Larson G (2004). "Cloning and sequencing of nineteen transcript isoforms of the human alpha2,3-sialyltransferase gene, ST3Gal III; its genomic organisation and expression in human tissues". Glycoconj. J. 19 (3): 197–210. doi:10.1023/A:1024253808424. PMID 12815231.
- Gretschel S, Haensch W, Schlag PM, Kemmner W (2003). "Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer". Oncology. 65 (2): 139–45. doi:10.1159/000072339. PMID 12931020.
- Jeanneau C, Chazalet V, Augé C; et al. (2004). "Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif". J. Biol. Chem. 279 (14): 13461–8. doi:10.1074/jbc.M311764200. PMID 14722111.
- Grahn A, Barkhordar GS, Larson G (2005). "Identification of seven new alpha2,3-sialyltransferase III, ST3Gal III, transcripts from human foetal brain". Glycoconj. J. 20 (7–8): 493–500. doi:10.1023/B:GLYC.0000038295.87747.0b. PMID 15316282.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Van Dyken SJ, Green RS, Marth JD (2007). "Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis". Mol. Cell. Biol. 27 (3): 1096–111. doi:10.1128/MCB.01750-06. PMID 17101770.
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