STAU1

Staufen, RNA binding protein, homolog 1 (Drosophila)
Identifiers
Symbols	STAU1 ; FLJ25010; STAU
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3384
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE STAU1 208948 s at tn.png
File:PBB GE STAU1 207320 x at tn.png
File:PBB GE STAU1 211505 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Staufen, RNA binding protein, homolog 1 (Drosophila), also known as STAU1, is a human gene.

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.

Further reading

• Kiebler MA, DesGroseillers L (2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. PMID 10707969.
• DesGroseillers L, Lemieux N (1997). "Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization". Genomics. 36 (3): 527–9. doi:10.1006/geno.1996.0499. PMID 8884277.
• Marión RM, Fortes P, Beloso A; et al. (1999). "A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum". Mol. Cell. Biol. 19 (3): 2212–9. PMID 10022908.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wickham L, Duchaîne T, Luo M; et al. (1999). "Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum". Mol. Cell. Biol. 19 (3): 2220–30. PMID 10022909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Falcón AM, Fortes P, Marión RM; et al. (1999). "Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro". Nucleic Acids Res. 27 (11): 2241–7. PMID 10325410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mouland AJ, Mercier J, Luo M; et al. (2000). "The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation". J. Virol. 74 (12): 5441–51. PMID 10823848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Monshausen M, Rehbein M, Richter D, Kindler S (2002). "The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1". J. Neurochem. 81 (3): 557–64. PMID 12065664.CS1 maint: Multiple names: authors list (link)
• Luo M, Duchaîne TF, DesGroseillers L (2002). "Molecular mapping of the determinants involved in human Staufen-ribosome association". Biochem. J. 365 (Pt 3): 817–24. doi:10.1042/ . PMID 12133005.CS1 maint: Multiple names: authors list (link)
• Ohashi S, Koike K, Omori A; et al. (2002). "Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor". J. Biol. Chem. 277 (40): 37804–10. doi:10.1074/jbc.M203608200. PMID 12147688.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Angenstein F, Evans AM, Settlage RE; et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. PMID 12388589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macchi P, Kroening S, Palacios IM; et al. (2003). "Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner". J. Neurosci. 23 (13): 5778–88. PMID 12843282.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chatel-Chaix L, Clément JF, Martel C; et al. (2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Mol. Cell. Biol. 24 (7): 2637–48. PMID 15024055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMID 15121898.CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brendel C, Rehbein M, Kreienkamp HJ; et al. (2005). "Characterization of Staufen 1 ribonucleoprotein complexes". Biochem. J. 384 (Pt 2): 239–46. doi:10.1042/BJ20040812. PMID 15303970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)