STX2
| Syntaxin 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | STX2 ; EPIM; EPM; MGC51014; STX2A; STX2B; STX2C | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37559 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE STX2 213434 at tn.png | |||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Syntaxin 2, also known as STX2, is a human gene.[1]
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]
References
Further reading
- Hirai Y, Takebe K, Takashina M; et al. (1992). "Epimorphin: a mesenchymal protein essential for epithelial morphogenesis". Cell. 69 (3): 471–81. PMID 1581962.
- Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. PMID 7768895.
- Li C, Ullrich B, Zhang JZ; et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
- Hirai Y (1993). "Molecular cloning of human epimorphin: identification of isoforms and their unique properties". Biochem. Biophys. Res. Commun. 191 (3): 1332–7. doi:10.1006/bbrc.1993.1363. PMID 8466509.
- Oka Y, Hirai Y (1996). "Inductive influences of epimorphin on endothelial cells in vitro". Exp. Cell Res. 222 (1): 189–98. doi:10.1006/excr.1996.0024. PMID 8549663.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Zha H, Remmers EF, Szpirer C; et al. (1997). "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12". Genomics. 37 (3): 386–9. doi:10.1006/geno.1996.0574. PMID 8938452.
- Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. 272 (4): 2520–6. PMID 8999968.
- Tellam JT, Macaulay SL, McIntosh S; et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. PMID 9045631.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Koshida S, Hirai Y (1997). "Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis". Biochem. Biophys. Res. Commun. 234 (2): 522–5. doi:10.1006/bbrc.1997.6673. PMID 9177305.
- Hirai Y, Lochter A, Galosy S; et al. (1998). "Epimorphin functions as a key morphoregulator for mammary epithelial cells". J. Cell Biol. 140 (1): 159–69. PMID 9425164.
- Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell. 10 (7): 2285–95. PMID 10397765.
- Pabst S, Hazzard JW, Antonin W; et al. (2000). "Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions". J. Biol. Chem. 275 (26): 19808–18. doi:10.1074/jbc.M002571200. PMID 10777504.
- Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Terasaki Y, Fukuda Y, Suga M; et al. (2006). "Epimorphin expression in interstitial pneumonia". Respir. Res. 6: 6. doi:10.1186/1465-9921-6-6. PMID 15651999.
- Band AM, Kuismanen E (2006). "Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments". BMC Cell Biol. 6 (1): 26. doi:10.1186/1471-2121-6-26. PMID 15943887.
- Low SH, Vasanji A, Nanduri J; et al. (2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Mol. Biol. Cell. 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMID 16339081.
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