SULT1E1

Sulfotransferase family 1E, estrogen-preferring, member 1
File:PBB Protein SULT1E1 image.jpg PDB rendering based on 1g3m.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1g3m​, 1hy3​
Identifiers
Symbols	SULT1E1 ; EST; EST-1; MGC34459; STE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68469
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SULT1E1 219934 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sulfotransferase family 1E, estrogen-preferring, member 1, also known as SULT1E1, is a human gene.

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA; et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. PMID 9034160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glatt H, Engelke CE, Pabel U; et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112-113: 341–8. PMID 10720750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. PMID 11154739.
• Glatt H, Boeing H, Engelke CE; et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. PMID 11535246.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Falany CN, Krasnykh V, Falany JL (1995). "Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase". J. Steroid Biochem. Mol. Biol. 52 (6): 529–39. PMID 7779757.CS1 maint: Multiple names: authors list (link)
• Bernier F, Leblanc G, Labrie F, Luu-The V (1994). "Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene". J. Biol. Chem. 269 (45): 28200–5. PMID 7961757.CS1 maint: Multiple names: authors list (link)
• Aksoy IA, Wood TC, Weinshilboum R (1994). "Human liver estrogen sulfotransferase: identification by cDNA cloning and expression". Biochem. Biophys. Res. Commun. 200 (3): 1621–9. doi:10.1006/bbrc.1994.1637. PMID 8185618.CS1 maint: Multiple names: authors list (link)
• Her C, Aksoy IA, Kimura S; et al. (1996). "Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization". Genomics. 29 (1): 16–23. doi:10.1006/geno.1995.1210. PMID 8530066.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Falany JL, Falany CN (1996). "Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines". Cancer Res. 56 (7): 1551–5. PMID 8603401.
• Her C, Szumlanski C, Aksoy IA, Weinshilboum RM (1997). "Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation". Drug Metab. Dispos. 24 (12): 1328–35. PMID 8971138.CS1 maint: Multiple names: authors list (link)
• Song WC, Qian Y, Sun X, Negishi M (1997). "Cellular localization and regulation of expression of testicular estrogen sulfotransferase". Endocrinology. 138 (11): 5006–12. PMID 9348232.CS1 maint: Multiple names: authors list (link)
• Rubin GL, Harrold AJ, Mills JA; et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy". Mol. Hum. Reprod. 5 (11): 995–1002. PMID 10541560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meinl W, Glatt H (2001). "Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene". Biochem. Biophys. Res. Commun. 288 (4): 855–62. doi:10.1006/bbrc.2001.5829. PMID 11688987.
• Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M (2002). "Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction". J. Biol. Chem. 277 (20): 17928–32. doi:10.1074/jbc.M111651200. PMID 11884392.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M (2003). "Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase". Environ. Health Perspect. 111 (7): 884–8. PMID 12782487.CS1 maint: Multiple names: authors list (link)