SUMO4
| SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) | |||||||||
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| Identifiers | |||||||||
| Symbols | SUMO4 ; IDDM5; SMT3H4; SUMO-4; dJ281H8.4 | ||||||||
| External IDs | Template:OMIM5 HomoloGene: 88399 | ||||||||
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| RNA expression pattern | |||||||||
| File:PBB GE SUMO4 215452 x at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), also known as SUMO4, is a human gene.[1]
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.[1]
References
Further reading
- Wang CY, Podolsky R, She JX (2007). "Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene". Ann. N. Y. Acad. Sci. 1079: 257–67. doi:10.1196/annals.1375.039. PMID 17130563.
- Davies JL, Kawaguchi Y, Bennett ST; et al. (1994). "A genome-wide search for human type 1 diabetes susceptibility genes". Nature. 371 (6493): 130–6. doi:10.1038/371130a0. PMID 8072542.
- Luo DF, Buzzetti R, Rotter JI; et al. (1997). "Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8". Hum. Mol. Genet. 5 (5): 693–8. PMID 8733139.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Bohren KM, Nadkarni V, Song JH; et al. (2004). "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". J. Biol. Chem. 279 (26): 27233–8. doi:10.1074/jbc.M402273200. PMID 15123604.
- Guo D, Li M, Zhang Y; et al. (2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nat. Genet. 36 (8): 837–41. doi:10.1038/ng1391. PMID 15247916.
- Smyth DJ, Howson JM, Lowe CE; et al. (2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nat. Genet. 37 (2): 110–1, author reply 112-3. doi:10.1038/ng0205-110. PMID 15678134.
- Qu H, Bharaj B, Liu XQ; et al. (2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nat. Genet. 37 (2): 111–2, author reply 112-3. doi:10.1038/ng0205-111. PMID 15678135.
- Park Y, Park S, Kang J; et al. (2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nat. Genet. 37 (2): 112, author reply 112-3. doi:10.1038/ng0205-112a. PMID 15678137.
- Owerbach D, McKay EM, Yeh ET; et al. (2005). "A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation". Biochem. Biophys. Res. Commun. 337 (2): 517–20. doi:10.1016/j.bbrc.2005.09.090. PMID 16198310.
- Guo D, Han J, Adam BL; et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
- Noso S, Ikegami H, Fujisawa T; et al. (2006). "Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes". Diabetes. 54 (12): 3582–6. PMID 16306380.
- Tsurumaru M, Kawasaki E, Ida H; et al. (2006). "Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population". J. Clin. Endocrinol. Metab. 91 (8): 3138–43. doi:10.1210/jc.2006-0206. PMID 16735488.
- Costas J, Perez-Pampin E, Ferreiros-Vidal I; et al. (2006). "SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis". J. Rheumatol. 33 (6): 1048–51. PMID 16755651.
- Sedimbi SK, Shastry A, Park Y; et al. (2007). "Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients". Ann. N. Y. Acad. Sci. 1079: 273–7. doi:10.1196/annals.1375.041. PMID 17130565.
- Lin HY, Wang CL, Hsiao PJ; et al. (2007). "SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes". Diabetes. 56 (4): 1177–80. doi:10.2337/db06-1283. PMID 17229939.
- Sedimbi SK, Kanungo A, Shastry A; et al. (2007). "No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients". Int. J. Immunogenet. 34 (2): 137–42. doi:10.1111/j.1744-313X.2007.00668.x. PMID 17373940.
- Noso S, Fujisawa T, Kawabata Y; et al. (2007). "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population". J. Clin. Endocrinol. Metab. 92 (6): 2358–62. doi:10.1210/jc.2007-0031. PMID 17374705.
- Bohren KM, Gabbay KH, Owerbach D (2007). "Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin". Protein Expr. Purif. 54 (2): 289–94. doi:10.1016/j.pep.2007.03.013. PMID 17459725.
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