SUZ12

Suppressor of zeste 12 homolog (Drosophila)
Identifiers
Symbols	SUZ12 ; CHET9; JJAZ1; KIAA0160
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32256
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SUZ12 212287 at tn.png
File:PBB GE SUZ12 213971 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Suppressor of zeste 12 homolog (Drosophila), also known as SUZ12, is a human gene.

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.

Further reading

• Nagase T, Seki N, Tanaka A; et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koontz JI, Soreng AL, Nucci M; et al. (2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6348–53. doi:10.1073/pnas.101132598. PMID 11371647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birve A, Sengupta AK, Beuchle D; et al. (2001). "Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants". Development. 128 (17): 3371–9. PMID 11546753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weinmann AS, Bartley SM, Zhang T; et al. (2001). "Use of chromatin immunoprecipitation to clone novel E2F target promoters". Mol. Cell. Biol. 21 (20): 6820–32. doi:10.1128/MCB.21.20.6820-6832.2001. PMID 11564866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao R, Wang L, Wang H; et al. (2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science. 298 (5595): 1039–43. doi:10.1126/science.1076997. PMID 12351676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuzmichev A, Nishioka K, Erdjument-Bromage H; et al. (2002). "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein". Genes Dev. 16 (22): 2893–905. doi:10.1101/gad.1035902. PMID 12435631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petek E, Jenne DE, Smolle J; et al. (2003). "Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations". J. Med. Genet. 40 (7): 520–5. PMID 12843325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang H, An W, Cao R; et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell. 12 (2): 475–87. PMID 14536086.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang HY, Ladanyi M, Soslow RA (2004). "Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity". Am. J. Surg. Pathol. 28 (2): 224–32. PMID 15043312.CS1 maint: Multiple names: authors list (link)
• Cao R, Zhang Y (2004). "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Mol. Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
• Kehrer-Sawatzki H, Kluwe L, Sandig C; et al. (2004). "High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene". Am. J. Hum. Genet. 75 (3): 410–23. doi:10.1086/423624. PMID 15257518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasini D, Bracken AP, Jensen MR; et al. (2004). "Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity". EMBO J. 23 (20): 4061–71. doi:10.1038/sj.emboj.7600402. PMID 15385962.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cha TL, Zhou BP, Xia W; et al. (2005). "Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3". Science. 310 (5746): 306–10. doi:10.1126/science.1118947. PMID 16224021.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee TI, Jenner RG, Boyer LA; et al. (2006). "Control of developmental regulators by Polycomb in human embryonic stem cells". Cell. 125 (2): 301–13. doi:10.1016/j.cell.2006.02.043. PMID 16630818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furuno K, Masatsugu T, Sonoda M; et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro". Biochem. Biophys. Res. Commun. 345 (3): 1051–8. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nucci MR, Harburger D, Koontz J; et al. (2007). "Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms". Am. J. Surg. Pathol. 31 (1): 65–70. doi:10.1097/01.pas.0000213327.86992.d1. PMID 17197920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)