SYNPO
| Synaptopodin | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SYNPO ; KIAA1029 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 5274 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SYNPO 202796 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Synaptopodin, also known as SYNPO, is a human gene.[1]
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM][1]
References
Further reading
- Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Mundel P, Heid HW, Mundel TM; et al. (1998). "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes". J. Cell Biol. 139 (1): 193–204. PMID 9314539.
- Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Patrie KM, Drescher AJ, Welihinda A; et al. (2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
- He JC, Husain M, Sunamoto M; et al. (2004). "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways". J. Clin. Invest. 114 (5): 643–51. doi:10.1172/JCI200421004. PMID 15343382.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Kremerskothen J, Plaas C, Kindler S; et al. (2005). "Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein". J. Neurochem. 92 (3): 597–606. doi:10.1111/j.1471-4159.2004.02888.x. PMID 15659229.
- Asanuma K, Kim K, Oh J; et al. (2005). "Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner". J. Clin. Invest. 115 (5): 1188–98. doi:10.1172/JCI200523371. PMID 15841212.
- Husain M, D'Agati VD, He JC; et al. (2006). "HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN". AIDS. 19 (17): 1975–80. PMID 16260903.
- Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
- Hirakawa M, Tsuruya K, Yotsueda H; et al. (2006). "Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis". Life Sci. 79 (8): 757–63. doi:10.1016/j.lfs.2006.02.031. PMID 16564554.
- Asanuma K, Yanagida-Asanuma E, Faul C; et al. (2006). "Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling". Nat. Cell Biol. 8 (5): 485–91. doi:10.1038/ncb1400. PMID 16622418.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Garovic VD, Wagner SJ, Petrovic LM; et al. (2007). "Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia". Nephrol. Dial. Transplant. 22 (4): 1136–43. doi:10.1093/ndt/gfl711. PMID 17255128.
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