Sequestosome 1

Sequestosome 1
File:PBB Protein SQSTM1 image.jpg PDB rendering based on 1q02.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q02​
Identifiers
Symbols	SQSTM1 ; p60; A170; OSIL; PDB3; ZIP3; p62; p62B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31202
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SQSTM1 201471 s at tn.png
File:PBB GE SQSTM1 213112 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sequestosome 1, also known as SQSTM1, is a human gene.

Further reading

• Geetha T, Wooten MW (2002). "Structure and functional properties of the ubiquitin binding protein p62". FEBS Lett. 512 (1–3): 19–24. PMID 11852044.
• Layfield R, Ciani B, Ralston SH; et al. (2005). "Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone". Biochem. Soc. Trans. 32 (Pt 5): 728–30. doi:10.1042/BST0320728. PMID 15493999.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Michou L, Collet C, Laplanche JL; et al. (2006). "Genetics of Paget's disease of bone". Joint Bone Spine. 73 (3): 243–8. doi:10.1016/j.jbspin.2005.05.009. PMID 16574459.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Devergne O, Hummel M, Koeppen H; et al. (1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. PMID 8551575.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park I, Chung J, Walsh CT; et al. (1996). "Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12338–42. PMID 8618896.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joung I, Strominger JL, Shin J (1996). "Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 5991–5. PMID 8650207.CS1 maint: Multiple names: authors list (link)
• Iyer N, Reagan MS, Wu KJ; et al. (1996). "Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124. PMID 8652557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vadlamudi RK, Joung I, Strominger JL, Shin J (1996). "p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins". J. Biol. Chem. 271 (34): 20235–7. PMID 8702753.CS1 maint: Multiple names: authors list (link)
• Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. PMID 8910285.CS1 maint: Multiple names: authors list (link)
• Jallal B, Mossie K, Vasiloudis G; et al. (1997). "The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase". J. Biol. Chem. 272 (18): 12158–63. PMID 9115287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanchez P, De Carcer G, Sandoval IV; et al. (1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Mol. Cell. Biol. 18 (5): 3069–80. PMID 9566925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vadlamudi RK, Shin J (1998). "Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein". FEBS Lett. 435 (2–3): 138–42. PMID 9762895.
• Sanz L, Sanchez P, Lallena MJ; et al. (1999). "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation". EMBO J. 18 (11): 3044–53. doi:10.1093/emboj/18.11.3044. PMID 10356400.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stumptner C, Heid H, Fuchsbichler A; et al. (1999). "Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent". Am. J. Pathol. 154 (6): 1701–10. PMID 10362795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sudo T, Maruyama M, Osada H (2000). "p62 functions as a p38 MAP kinase regulator". Biochem. Biophys. Res. Commun. 269 (2): 521–5. doi:10.1006/bbrc.2000.2333. PMID 10708586.CS1 maint: Multiple names: authors list (link)
• Sanz L, Diaz-Meco MT, Nakano H, Moscat J (2000). "The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway". EMBO J. 19 (7): 1576–86. doi:10.1093/emboj/19.7.1576. PMID 10747026.CS1 maint: Multiple names: authors list (link)
• Wooten MW, Seibenhener ML, Mamidipudi V; et al. (2001). "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor". J. Biol. Chem. 276 (11): 7709–12. doi:10.1074/jbc.C000869200. PMID 11244088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuusisto E, Salminen A, Alafuzoff I (2001). "Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies". Neuroreport. 12 (10): 2085–90. PMID 11447312.CS1 maint: Multiple names: authors list (link)
• Laurin N, Brown JP, Lemainque A; et al. (2001). "Paget disease of bone: mapping of two loci at 5q35-qter and 5q31". Am. J. Hum. Genet. 69 (3): 528–43. PMID 11473345.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang S, Kim JH, Shin J (2002). "p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition". FEBS Lett. 510 (1–2): 57–61. PMID 11755531.CS1 maint: Multiple names: authors list (link)