Small nuclear ribonucleoprotein D1

Small nuclear ribonucleoprotein D1 polypeptide 16kDa
File:PBB Protein SNRPD1 image.jpg PDB rendering based on 1b34.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b34​
Identifiers
Symbols	SNRPD1 ; HsT2456; SMD1; SNRPD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5053
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SNRPD1 202690 s at tn.png
File:PBB GE SNRPD1 202691 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Small nuclear ribonucleoprotein D1 polypeptide 16kDa, also known as SNRPD1, is a human gene.

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.

Further reading

• Lehmeier T, Foulaki K, Lührmann R (1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. PMID 1701240.CS1 maint: Multiple names: authors list (link)
• Renz M, Heim C, Bräunling O; et al. (1989). "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases". Clin. Chem. 35 (9): 1861–3. PMID 2528429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. PMID 3260384.CS1 maint: Multiple names: authors list (link)
• Lehmeier T, Raker V, Hermann H, Lührmann R (1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12317–21. PMID 7527560.CS1 maint: Multiple names: authors list (link)
• Sun D, Ou YC, Hoch SO (1997). "Analysis of genes for human snRNP Sm-D1 protein and identification of the promoter sequence which shows segmental homology to the promoters of Sm-E and U1 snRNA genes". Gene. 189 (2): 245–54. PMID 9168134.CS1 maint: Multiple names: authors list (link)
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. PMID 9323129.CS1 maint: Multiple names: authors list (link)
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.CS1 maint: Multiple names: authors list (link)
• Kambach C, Walke S, Young R; et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. PMID 10025403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charroux B, Pellizzoni L, Perkinson RA; et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. PMID 10601333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charroux B, Pellizzoni L, Perkinson RA; et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. PMID 10725331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mammoto A, Sasaki T, Kim Y, Takai Y (2000). "Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking". J. Biol. Chem. 275 (18): 13167–70. PMID 10747849.CS1 maint: Multiple names: authors list (link)
• Brahms H, Raymackers J, Union A; et al. (2000). "The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies". J. Biol. Chem. 275 (22): 17122–9. doi:10.1074/jbc.M000300200. PMID 10747894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meister G, Bühler D, Laggerbauer B; et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. PMID 10942426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ajuh P, Kuster B, Panov K; et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMID 11101529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Selenko P, Sprangers R, Stier G; et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMID 11226169.CS1 maint: Multiple names: authors list (link)
• Friesen WJ, Massenet S, Paushkin S; et al. (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets". Mol. Cell. 7 (5): 1111–7. PMID 11389857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park JW, Voss PG, Grabski S; et al. (2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 (17): 3595–602. PMID 11522829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Friesen WJ, Paushkin S, Wyce A; et al. (2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMID 11713266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gubitz AK, Mourelatos Z, Abel L; et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)