Sortilin 1
| Sortilin 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SORT1 ; NT3; Gp95 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 39282 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SORT1 212797 at tn.png | |||||||||||
| File:PBB GE SORT1 212807 s at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Sortilin 1, also known as SORT1, is a human gene.[1]
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.[1]
See also
References
Further reading
- Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors". Trends Pharmacol. Sci. 20 (7): 302–9. PMID 10390649.
- Mazella J (2001). "Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?". Cell. Signal. 13 (1): 1–6. PMID 11257441.
- Petersen CM, Nielsen MS, Nykjaer A; et al. (1997). "Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography". J. Biol. Chem. 272 (6): 3599–605. PMID 9013611.
- Lin BZ, Pilch PF, Kandror KV (1997). "Sortilin is a major protein component of Glut4-containing vesicles". J. Biol. Chem. 272 (39): 24145–7. PMID 9305862.
- Tauris J, Ellgaard L, Jacobsen C; et al. (1998). "The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin". FEBS Lett. 429 (1): 27–30. PMID 9657377.
- Mazella J, Zsürger N, Navarro V; et al. (1998). "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor". J. Biol. Chem. 273 (41): 26273–6. PMID 9756851.
- Munck Petersen C, Nielsen MS, Jacobsen C; et al. (1999). "Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding". EMBO J. 18 (3): 595–604. doi:10.1093/emboj/18.3.595. PMID 9927419.
- Nielsen MS, Jacobsen C, Olivecrona G; et al. (1999). "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase". J. Biol. Chem. 274 (13): 8832–6. PMID 10085125.
- Nielsen MS, Madsen P, Christensen EI; et al. (2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". EMBO J. 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. PMID 11331584.
- Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi:10.1074/jbc.C100218200. PMID 11390366.
- Hampe W, Rezgaoui M, Hermans-Borgmeyer I, Schaller HC (2001). "The genes for the human VPS10 domain-containing receptors are large and contain many small exons". Hum. Genet. 108 (6): 529–36. PMID 11499680.
- Shiba T, Takatsu H, Nogi T; et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature. 415 (6874): 937–41. doi:10.1038/415937a. PMID 11859376.
- Maeda S, Nobukuni T, Shimo-Onoda K; et al. (2002). "Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization". J. Cell. Physiol. 193 (1): 73–9. doi:10.1002/jcp.10151. PMID 12209882.
- Martin S, Navarro V, Vincent JP, Mazella J (2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line". Gastroenterology. 123 (4): 1135–43. PMID 12360476.
- Navarro V, Vincent JP, Mazella J (2003). "Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line". Biochem. Biophys. Res. Commun. 298 (5): 760–4. PMID 12419319.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Martin S, Vincent JP, Mazella J (2003). "Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia". J. Neurosci. 23 (4): 1198–205. PMID 12598608.
- Lefrancois S, Zeng J, Hassan AJ; et al. (2004). "The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin". EMBO J. 22 (24): 6430–7. doi:10.1093/emboj/cdg629. PMID 14657016.
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