TACSTD2

Tumor-associated calcium signal transducer 2
Identifiers
Symbols	TACSTD2 ; EGP-1; GA733; GA733-1; M1S1; TROP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1763
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TACSTD2 202286 s at tn.png
File:PBB GE TACSTD2 202287 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tumor-associated calcium signal transducer 2, also known as TACSTD2, is a human gene.

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

Further reading

• Linnenbach AJ, Wojcierowski J, Wu SA; et al. (1989). "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 27–31. PMID 2911574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fornaro M, Dell'Arciprete R, Stella M; et al. (1995). "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas". Int. J. Cancer. 62 (5): 610–8. PMID 7665234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Linnenbach AJ, Seng BA, Wu S; et al. (1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol. Cell. Biol. 13 (3): 1507–15. PMID 8382772.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• El Sewedy T, Fornaro M, Alberti S (1998). "Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2". Int. J. Cancer. 75 (2): 324–30. PMID 9462726.CS1 maint: Multiple names: authors list (link)
• Ripani E, Sacchetti A, Corda D, Alberti S (1998). "Human Trop-2 is a tumor-associated calcium signal transducer". Int. J. Cancer. 76 (5): 671–6. PMID 9610724.CS1 maint: Multiple names: authors list (link)
• Tsujikawa M, Kurahashi H, Tanaka T; et al. (1999). "Identification of the gene responsible for gelatinous drop-like corneal dystrophy". Nat. Genet. 21 (4): 420–3. doi:10.1038/7759. PMID 10192395.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Nishida K, Dota A; et al. (2000). "Gelatino-lattice corneal dystrophy: clinical features and mutational analysis". Am. J. Ophthalmol. 129 (5): 665–6. PMID 10844062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kinoshita S, Nishida K, Dota A; et al. (2000). "Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy". Cornea. 19 (4): 551–5. PMID 10928776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsujikawa M, Tsujikawa K, Maeda N; et al. (2000). "Rapid detection of M1S1 mutations by the protein truncation test". Invest. Ophthalmol. Vis. Sci. 41 (9): 2466–8. PMID 10937555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ha NT, Fujiki K, Hotta Y; et al. (2000). "Q118X mutation of M1S1 gene caused gelatinous drop-like corneal dystrophy: the P501T of BIGH3 gene found in a family with gelatinous drop-like corneal dystrophy". Am. J. Ophthalmol. 130 (1): 119–20. PMID 11004271.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Calabrese G, Crescenzi C, Morizio E; et al. (2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet. Cell Genet. 92 (1–2): 164–5. PMID 11306819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tasa G, Kals J, Muru K; et al. (2001). "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy". Invest. Ophthalmol. Vis. Sci. 42 (12): 2762–4. PMID 11687514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshida S, Kumano Y, Yoshida A; et al. (2002). "Two brothers with gelatinous drop-like dystrophy at different stages of the disease: role of mutational analysis". Am. J. Ophthalmol. 133 (6): 830–2. PMID 12036680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ren Z, Lin PY, Klintworth GK; et al. (2002). "Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy". Hum. Genet. 110 (6): 568–77. doi:10.1007/s00439-002-0729-z. PMID 12107443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ha NT, Chau HM, Cung le X; et al. (2003). "A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy". Am. J. Ophthalmol. 135 (3): 390–3. PMID 12614764.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gires O, Eskofier S, Lang S; et al. (2003). "Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter". Anticancer Res. 23 (4): 3255–61. PMID 12926061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian X, Fujiki K, Li Q; et al. (2004). "Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy". Am. J. Ophthalmol. 137 (3): 567–9. doi:10.1016/j.ajo.2003.08.008. PMID 15013888.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murakami A, Kimura S, Fujiki K; et al. (2004). "Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy". Jpn. J. Ophthalmol. 48 (4): 317–20. doi:10.1007/s10384-003-0064-5. PMID 15295654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)