TCEA2

Transcription elongation factor A (SII), 2
File:PBB Protein TCEA2 image.jpg PDB rendering based on 1tfi.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1tfi​
Identifiers
Symbols	TCEA2 ; TFIIS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68304
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TCEA2 203919 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transcription elongation factor A (SII), 2, also known as TCEA2, is a human gene.

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kato H, Sumimoto H, Pognonec P; et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. PMID 1559613.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Umehara T, Kida S, Yamamoto T, Horikoshi M (1996). "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II". Gene. 167 (1–2): 297–302. PMID 8566795.CS1 maint: Multiple names: authors list (link)
• Weaver ZA, Kane CM (1998). "Genomic characterization of a testis-specific TFIIS (TCEA2) gene". Genomics. 46 (3): 516–9. doi:10.1006/geno.1997.5073. PMID 9441762.
• Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. PMID 9765201.
• Trembley JH, Hu D, Hsu LC; et al. (2002). "PITSLRE p110 protein kinases associate with transcription complexes and affect their activity". J. Biol. Chem. 277 (4): 2589–96. doi:10.1074/jbc.M109755200. PMID 11709559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sijbrandi R, Fiedler U, Timmers HT (2002). "RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage". Nucleic Acids Res. 30 (11): 2290–8. PMID 12034815.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. PMID 12761297.CS1 maint: Multiple names: authors list (link)
• Tamura K, Miyata K, Sugahara K; et al. (2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochem. Biophys. Res. Commun. 309 (1): 189–95. PMID 12943681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakata A, Ito T, Nagata M; et al. (2005). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palangat M, Renner DB, Price DH, Landick R (2005). "A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS". Proc. Natl. Acad. Sci. U.S.A. 102 (42): 15036–41. doi:10.1073/pnas.0409405102. PMID 16214896.CS1 maint: Multiple names: authors list (link)
• Kuraoka I, Suzuki K, Ito S; et al. (2007). "RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS". DNA Repair (Amst.). 6 (6): 841–51. doi:10.1016/j.dnarep.2007.01.014. PMID 17374514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)